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oai:repisalud.isciii.es:20.500.12105/252772024-10-23T13:07:22Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16958

00925njm 22002777a 4500 dc García-Heredia, José Manuel author Carnero, Amancio author 2020-07-15 Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to different cytotoxic drugs or radiotherapy, as well as with tumor relapse and a poor prognosis. Various studies have shown that mitochondria play a central role in these processes because of the ability of this organelle to modify cell metabolism, allowing survival and avoiding apoptosis clearance of cancer cells. Thus, the whole mitochondrial cycle, from its biogenesis to its death, either by mitophagy or by apoptosis, can be targeted by different drugs to reduce mitochondrial fitness, allowing for a restored or increased sensitivity to chemotherapeutic drugs. Once mitochondrial misbalance is induced by a specific drug in any of the processes of mitochondrial metabolism, two elements are commonly boosted: an increment in reactive nitrogen/oxygen species and, subsequently, activation of the intrinsic apoptotic pathway. 10.3390/cells9071693 2073-4409 Cells http://hdl.handle.net/10668/15954 32679735 https://hdl.handle.net/20.500.12105/25277 Cancer stem cells Drug resistance Metabolic plasticity Mitochondria Role of Mitochondria in Cancer Stem Cell Resistance.