2026-06-14T02:17:20Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/252762024-10-23T13:07:22Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16958
Repisalud
author
Muñoz-Galván, Sandra
author
Carnero, Amancio
2024-10-23T13:07:22Z
2024-10-23T13:07:22Z
2020-06-04
10.3390/cells9061402
2073-4409
Cells
http://hdl.handle.net/10668/15700
32512891
https://hdl.handle.net/20.500.12105/25276
Ovarian cancer is the most lethal gynecological malignancy due to its late detection and high recurrence rate. Resistance to conventional platinum-based therapies and metastasis are attributed to a population of cells within tumors called cancer stem cells, which possess stem-like features and are able to recapitulate new tumors. Recent studies have deepened the understanding of the biology of ovarian cancer stem cells and their special properties and have identified multiple markers and signaling pathways responsible for their self-renewal abilities. Targeting cancer stem cells represents the most promising strategy for overcoming therapy resistance and reducing mortality in ovarian cancer, but further efforts must be made to improve our understanding of the mechanisms involved in therapy resistance. In this review, we summarize our current knowledge about ovarian cancer stem cells, their involvement in metastasis and their interactions with the tumor microenvironment; we also discuss the therapeutic approaches that are being developed to target them to prevent tumor relapse.
eng
Cancer stem cells
Ovarian cancer
Therapy resistance
Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer.
research article