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oai:repisalud.isciii.es:20.500.12105/252542024-10-23T10:07:13Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16958
Repisalud author Huertas-Castaño, Carlos author Gómez-Muñoz, María A author Pardal, Ricardo author Vega, Francisco M 2024-10-23T10:07:13Z 2024-10-23T10:07:13Z 2019-12-19 10.3390/ijms21010039 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/3768 31861671 https://hdl.handle.net/20.500.12105/25254 Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tissue oxygen concentration has emerged as a cellular stimulus with important consequences for tumour initiation, evolution and progression. In neuroblastoma, several evidences point towards a role of hypoxia in tumour initiation during development, tumour cell differentiation, survival and metastatic spreading. However, the heterogeneous nature of the disease, its developmental origin and the lack of suitable experimental models have complicated a clear understanding of the effect of hypoxia in neuroblastoma tumour progression and the molecular mechanisms implicated. In this review, we have compiled available evidences to try to shed light onto this important field. In particular, we explore the effect of hypoxia in neuroblastoma cell transformation and differentiation. We also discuss the experimental models available and the emerging alternatives to study this problem, and we present hypoxia-related therapeutic avenues being explored in the field. eng Cancer stem cells Hypoxia Neural crest cells Neuroblastoma Paediatric oncology Hypoxia in the Initiation and Progression of Neuroblastoma Tumours. research article