2026-07-21T11:39:00Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/252052024-10-23T09:08:07Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Montañez-Heredia, Elvira author Irizar, Sofia author Huertas, Pedro J author Otero, Esperanza author Del Valle, Marta author Prat, Isidro author Díaz-Gallardo, Macarena S author Perón, Macarena author Marchal, Juan A author Hernandez-Lamas, María Del Carmen 2024-10-23T09:08:07Z 2024-10-23T09:08:07Z 2016-07-02 10.3390/ijms17071064 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/10247 27384560 https://hdl.handle.net/20.500.12105/25205 Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous PRP versus hyaluronic acid (HA) in knee osteoarthritis. PRP was manufactured in Malaga's Regional Blood Center (Spain). Patients that met the eligibility criteria were randomized into a PRP group or a HA group. Pain and functional improvements were assessed pre- and post-treatment (three and six months follow-up) using the Visual Analogue Scale (VAS); the Knee and Osteoarthritis Outcome System (KOOS) scale and the European Quality of Life scale (EUROQOL). Both groups presented pain reduction at six months. The VAS scores for the PRP group improved by at least 50% from their initial value, particularly at three months following the final infiltration, with results resembling those of the HA group at six months. PRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades. eng Clinical trial Hyaluronic acid Knee osteoarthritis Platelet-rich plasma Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System research article