2026-08-29T10:33:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/250962025-12-18T13:01:00Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19618col_20.500.12105_19617
Repisalud
author
Montero-Calle, Ana Maria
author
Garranzo-Asensio, Maria
author
Moreno-Casbas, Teresa
author
Campuzano, Susana
author
Barderas Manchado, Rodrigo
funder
Instituto de Salud Carlos III
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. European Innovation Council (EIC)
2024-10-14T10:14:02Z
2024-10-14T10:14:02Z
2024
Front Immunol. 2024 Aug 21:15:1455602.
10.3389/fimmu.2024.1455602
1664-3224
Frontiers in immunology
39234247
https://hdl.handle.net/20.500.12105/25096
Although blood autoantibodies were initially associated with autoimmune diseases, multiple evidence have been accumulated showing their presence in many types of cancer. This has opened their use in clinics, since cancer autoantibodies might be useful for early detection, prognosis, and monitoring of cancer patients. In this review, we discuss the different techniques available for their discovery and validation. Additionally, we discuss here in detail those autoantibody panels verified in at least two different reports that should be more likely to be specific of each of the four most incident cancers. We also report the recent developed kits for breast and lung cancer detection mostly based on autoantibodies and the identification of novel therapeutic targets because of the screening of the cancer humoral immune response. Finally, we discuss unsolved issues that still need to be addressed for the implementation of cancer autoantibodies in clinical routine for cancer diagnosis, prognosis, and/or monitoring.
eng
Autoantibodies
Breast cancer
Cancer autoantibodies
Colorectal cancer
Humoral immune response
Lung cancer
Prostate cancer
Proteomics
Autoantibodies in cancer: a systematic review of their clinical role in the most prevalent cancers
review article
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URL
https://repisalud.isciii.es/bitstreams/cf59fd34-92c7-45f6-8e77-f5f40558a182/download
File
MD5
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AutoantibodiesCancerSystematicReview_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/caa9df8b-40d7-4949-8276-832134e338d5/download
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AutoantibodiesCancerSystematicReview_2024.pdf.txt