2026-05-22T00:06:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/250932025-12-18T12:59:02Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Parambath, Sarika
author
Dao, Aiken
author
Kim, Hannah Yejin
author
Zawahir, Shukry
author
Alastruey-Izquierdo, Ana
author
Tacconelli, Evelina
author
Govender, Nelesh P
author
Oladele, Rita
author
Colombo, Arnaldo
author
Sorrell, Tania
author
Ramon-Pardo, Pilar
author
Fusire, Terence
author
Gigante, Valeria
author
Sati, Hatim
author
Morrissey, C Orla
author
Alffenaar, Jan-Willem
author
Beardsley, Justin
funder
Federal Ministry of Education & Research (Alemania)
funder
Federal Ministry of Education, Science and Research (Austria)
2024-10-11T13:27:15Z
2024-10-11T13:27:15Z
2024-06-27
Med Mycol. 2024 Jun 27;62(6):myae045.
10.1093/mmy/myae045
1460-2709
1369-3786
Medical mycology
38935906
https://hdl.handle.net/20.500.12105/25093
Candida albicans is a common fungal pathogen and amongst the leading causes of invasive candidiasis globally. This systematic review examines the characteristics and global impact of invasive infections caused by C. albicans. We searched on PubMed and Web of Science for studies reporting on criteria such as mortality, morbidity, drug resistance, preventability, yearly incidence, and distribution/emergence during the period from 2016 to 2021. Our findings indicate that C. albicans is the most common Candida species causing invasive disease and that standard infection control measures are the primary means of prevention. However, we found high rates of mortality associated with infections caused by C. albicans. Furthermore, there is a lack of data on complications and sequelae. Resistance to commonly used antifungals remains rare. Although, whilst generally susceptible to azoles, we found some evidence of increasing resistance, particularly in middle-income settings-notably, data from low-income settings were limited. Candida albicans remains susceptible to echinocandins, amphotericin B, and flucytosine. We observed evidence of a decreasing proportion of infections caused by C. albicans relative to other Candida species, although detailed epidemiological studies are needed to confirm this trend. More robust data on attributable mortality, complications, and sequelae are needed to understand the full extent of the impact of invasive C. albicans infections.
eng
Candida albicans
Antifungal resistance
Epidemiology
Invasive candidiasis
Mortality
Candida albicans-A systematic review to inform the World Health Organization Fungal Priority Pathogens List
research article
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Correction_CandidaAlbicans-A_SystematicReview_2024.pdf
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CandidaAlbicans-A_SystematicReview_2024.pdf.txt
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