2026-05-17T05:52:38Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/238282024-11-29T00:33:47Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Tejada Gavela, Silvia author Sarubbo, Fiorella author Jiménez-Garcia, Manuel author Ramis, Margarida R author Monserrat-Mesquida, Margalida author Quetglas-Llabrés, Magdalena author Capó Fiol, Xavier author Esteban, Susana author Sureda Gomila, Antoni author Moranta, David 2024-10-09T07:09:18Z 2024-10-09T07:09:18Z 2024-01-26 Tejada S, Sarubbo F, Jiménez-García M, Ramis MR, Monserrat-Mesquida M, Quetglas-Llabrés MM, et al. Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60. Nutrients. 2024 Jan 26;16(3). 10.3390/nu1603036810.3390/nu16030368 2072-6643 Nutrients https://hdl.handle.net/20.500.13003/20208 38337652 2-s2.0-85184675107 https://hdl.handle.net/20.500.12105/23828 1160360400001 Aging is a normal physiological process influenced by the combination of multiple mechanisms, primarily oxidative stress and neuroinflammation, which impact general physiology and brain function. Phenolic compounds have demonstrated the ability to slow down the aging process of the brain due to their antioxidant and anti-inflammatory effects. This study assessed the protective properties of catechin and polyphenon-60 in non-pathologically aged rats regarding visuo-spatial learning and the oxidative status of the frontal cortex. Old animals were treated with catechin or green tea extract (polyphenon-60) for 36 days, daily. Healthy old and young rats were used as controls. During the first training phase, treated rats executed the test better, locating the target in less time compared with the controls. Biomarkers of oxidative stress (catalase activities, superoxide dismutase, glutathione reductase, and glutathione S-transferase) were reduced in the brain of old animals, although their activities were partially improved after both antioxidant treatments. Furthermore, the rise in the production of reactive oxygen species and malondialdehyde levels-a marker of lipid peroxidation-in the frontal cortex of aged animals was significantly ameliorated after the interventions. In conclusion, old rats exhibited enhanced cognitive function and reduced stress levels following the administration of catechin and polyphenon-60. eng Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60 research article