2026-05-17T05:46:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/237842024-11-29T03:28:57Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Abrego-Guandique, Diana Marisol author Bonet, M Luisa author Caroleo, Maria Cristina author Cannataro, Roberto author Tucci, Paola author Ribot, Joan author Cione, Erika author 2023-10-17 β-carotene is a powerful antioxidant and dietary precursor of vitamin A whose role in maintaining mental health and cognitive performance, either alone or in combination with other dietary compounds, has been a topic of recent research. However, its effectiveness is still unclear. This systematic review, conducted according to the PRISMA guideline and assisted by the MySLR platform, addressed this issue. A total of 16 eligible original research articles were identified. Dietary intake or β-carotene serum levels were associated with improved measures of cognitive function in 7 out of 10 epidemiological studies included. In intervention studies, β-carotene consumption alone did not promote better cognitive function in the short term, but only in a long-term intervention with a mean duration of 18 years. However, all but one intervention study suggested the beneficial effects of β-carotene supplementation at doses ranging from 6 mg to 50 mg per day in combination with a multicomplex such as vitamin E, vitamin C, zinc, or selenium for a period of 16 weeks to 20 years. Despite the current limitations, the available evidence suggests a potential association between β-carotene dietary/supplementary intake and the maintenance of cognitive function. The β-carotene most probably does not act alone but in synergy with other micronutrients. Abrego-Guandique DM, Bonet ML, Caroleo MC, Cannataro R, Tucci P, Ribot J, et al. The Effect of Beta-Carotene on Cognitive Function: A Systematic Review. Brain Sci. 2023 Oct 17;13(10):1468. 10.3390/brainsci13101468 2076-3425 Brain sciences https://hdl.handle.net/20.500.13003/19997 37891835 L2026330984 2-s2.0-85175195107 https://hdl.handle.net/20.500.12105/23784 The Effect of Beta-Carotene on Cognitive Function: A Systematic Review