2026-05-20T03:47:33Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/237812024-11-28T18:22:27Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16962col_20.500.12105_16963col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16969col_20.500.12105_16970col_20.500.12105_16973col_20.500.12105_16978col_20.500.12105_16979col_20.500.12105_16981col_20.500.12105_16982col_20.500.12105_16987col_20.500.12105_16988col_20.500.12105_16989
Repisalud
author
Gracia-Ahufinger, Irene
author
López-González, Laura
author
Vasallo, Francisco José
author
Galar, Alicia
author
Siller, María
author
Pitart, Cristina
author
Bloise, Iván
author
Torrecillas, Miriam
author
Gijón-Cordero, Desirée
author
Viñado, Belén
author
Castillo-García, Javier
author
Campo, Rainer
author
Mulet, Xavier
author
Madueño-Alonso, Ana
author
Chamizo-López, Francisco Javier
author
Arrastia-Erviti, Maitane
author
Galán-Sánchez, Fátima
author
Fernández-Quejo, Melisa
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Rodríguez-Díaz, Juan Carlos
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Gutiérrez-Zufiaurre, María Nieves
author
Rodríguez-Maresca, Manuel Angel
author
Ortega-Lafont, María Del Pilar
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Yague-Guirao, Genoveva
author
Chaves-Blanco, Lucía
author
Colomina-Rodríguez, Javier
author
Vidal-Acuña, María Reyes
author
Portillo, María Eugenia
author
Franco-Álvarez de Luna, Francisco
author
Centelles-Serrano, María José
author
Azcona-Gutiérrez, José Manuel
author
Delgado-Iribarren García Campero, Alberto
author
Rey-Cao, Sonia
author
Muñoz, Patricia
author
Calvo-Montes, Jorge
author
Zboromyrska, Yuliya
author
Grandioso, David
author
Càmara, Jordi
author
Cantón, Rafael
author
Larrosa-Escartín, Nieves
author
Díaz-Regañón, Jazmín
author
Martínez-Martínez, Luis
2024-10-09T06:36:27Z
2024-10-09T06:36:27Z
2023
Gracia-Ahufinger I, López-González L, Vasallo FJ, Galar A, Siller M, Pitart C, et al. The CARBA-MAP study: national mapping of carbapenemases in Spain (2014-2018). Front Microbiol. 2023 Sep 8;14.
10.3389/fmicb.2023.1247804
1664-302X
Frontiers in microbiology
https://hdl.handle.net/20.500.13003/19962
37744921
L2025536205
2-s2.0-85171867545
https://hdl.handle.net/20.500.12105/23781
1069977400001
Introduction: Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018. Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0. Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017-2018 compared to 2014-2016. Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms.
eng
The CARBA-MAP study: national mapping of carbapenemases in Spain (2014-2018)
research article