2026-07-22T03:37:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/237742024-11-28T19:36:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16988
Repisalud
author
Morales-Soriano, Rafael
author
Pineño-Flores, Cristina
author
Moron Canis, Jose Miguel
author
Molina Romero, Francesc Xavier
author
Rodríguez Pino, José Carlos
author
Loyola-Miró, Julia
author
González-Argenté, Francesc Xavier
author
Palma-Zamora, Elias
author
Guillot, Monica
author
Gimenez, Sandra
author
Alvarez-Mon, Melchor
author
Ortega, Miguel A
author
Segura-Sampedro, Juan José
2024-10-09T06:36:26Z
2024-10-09T06:36:26Z
2023-06-05
Morales-Soriano R, Pineño-Flores C, Moron-Canis JM, Molina-Romero FJ, Rodriguez-Pino JC, Loyola-Miró J, et al. Simultaneous Surgical Approach with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients with Concurrent Peritoneal and Liver Metastases of Colon Cancer Origin. J Clin Med. 2023 Jun 5;12(11):3860.
10.3390/jcm12113860
2077-0383
Journal of clinical medicine
https://hdl.handle.net/20.500.13003/19291
37298054
L2023702118
2-s2.0-85161281589
https://hdl.handle.net/20.500.12105/23774
1005484200001
Background: Simultaneous liver resection and peritoneal cytoreduction with hyperthermic intraperitoneal chemotherapy (HIPEC) remains controversial today. The aim of the study was to analyze the postoperative outcomes and survival of patients with advanced metastatic colon cancer (peritoneal and/or liver metastases). Methods: Retrospective observational study from a prospective maintained data base. Patients who underwent a simultaneous peritoneal cytoreduction and liver resection plus HIPEC were studied. Postoperative outcomes and overall and disease free survival were analyzed. Univariate and multivariate analyses were performed. Results: From January 2010 to October 2022, 22 patients operated with peritoneal and liver metastasis (LR+) were compared with 87 patients operated with peritoneal metastasis alone (LR-). LR+ group presented higher serious morbidity (36.4 vs. 14.9%; p: 0.034). Postoperative mortality did not reach statistical difference. Median overall and disease free survival was similar. Peritoneal carcinomatosis index was the only predictive factor of survival. Conclusions: Simultaneous peritoneal and liver resection is associated with increased postoperative morbidity and hospital stay, but with similar postoperative mortality and OS and disease free survival. These results reflect the evolution of these patients, considered inoperable until recently, and justify the trend to incorporate this surgical strategy within a multimodal therapeutic plan in highly selected patients.
eng
Simultaneous Surgical Approach with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients with Concurrent Peritoneal and Liver Metastases of Colon Cancer Origin
research article