2026-05-17T01:18:44Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/237682024-11-29T00:53:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Sarubbo, Fiorella author Ramis, Margarita author Tejada Gavela, Silvia author Jiménez-Garcia, Manuel author Esteban, Susana author Miralles, Antonio author Moranta, David author 2023 Strategies focus on the use of molecules found in food derived from plants as polyphenols, arouse interest for combating aging. The polyphenol resveratrol, due to its antioxidants and anti-inflammatory properties, is increasingly studied, being still unknown their effects on episodic-like memory and motor coordination. This research evaluated the in vivo effect of chronic resveratrol treatment (20 mg/kg/day, i.p, 28 days) in episodic-like memory and motor coordination in non-pathological old rats, comparing with young and old vehicle-treated rats, using the novel object recognition and the rotarod tests. In combination with the analyses of the effect of resveratrol on the immunoreactivity of the main molecular proteins involved in neuroinflammation (SIRT1, SIRT1-75 kDa fragment, NF-κB acetylation) in the hippocampus of these rats. Results suggest a beneficial effect of resveratrol on episodic-like memory and in motor coordination through modulating neuroinflammation, acting on SIRT1 and NF-?B signaling pathway in the hippocampus of old rats. Fiorella S, Margarita R, Silvia T, Manuel J-G, Susana E, A M, et al. Resveratrol improves episodic-like memory and motor coordination through modulating neuroinflammation in old rats. J Funct Foods. 2023 May;104:105533. 10.1016/j.jff.2023.105533 1756-4646 Journal of Functional Foods https://hdl.handle.net/20.500.13003/18919 2-s2.0-85151896291 https://hdl.handle.net/20.500.12105/23768 Resveratrol improves episodic-like memory and motor coordination through modulating neuroinflammation in old rats