2026-06-14T02:28:56Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/237562024-11-28T21:56:40Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Monserrat-Mesquida, Margalida author Bouzas, Cristina author Mascaró, Catalina M author Tejada Gavela, Silvia author Sureda Gomila, Antoni author 2023 Background: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, the prevalence of which has increased over the years. The management of this pathology is not clear, and a specific pharmacological drug that can treat NAFLD is not available. In this sense, efforts are focused on the potential use of compounds with a natural origin that can contribute to reversing hepatic steatosis. Supplementation with probiotics, live microorganisms, is a potential strategy for the management of NAFLD. Methods: In the present review, the available information on the potential therapeutic effects of probiotics in NAFLD, mainly in animal models and in some clinical trials, is summarized. Results: Studies carried out using animal models of NAFLD induced by a high-fat diet have shown the beneficial effects of probiotic supplementation in reducing liver steatosis and normalizing the blood lipid profile and liver enzyme activities. In addition, a decrease in lipogenesis and an increase in lipolysis have been observed, together with a reduction in the pro-oxidative and pro-inflammatory state and a normalization of intestinal dysbiosis. Clinical trials have reported a decrease in the serum transaminases and an improved lipid profile, as well as a reduction in inflammatory markers. Conclusions: In conclusion, probiotic supplementation can be used as a potential therapy for the management of NAFLD. Monserrat-Mesquida M, Bouzas C, Mascaró CM, Tejada S, Sureda A. Probiotics as Potential Therapy in the Management of Non-Alcoholic Fatty Liver Disease (NAFLD). Fermentation. 2023 Apr 19;9(4):395. 10.3390/fermentation9040395 2311-5637 Fermentation https://hdl.handle.net/20.500.13003/18962 2-s2.0-85153941323 https://hdl.handle.net/20.500.12105/23756 977308800001 Probiotics as Potential Therapy in the Management of Non-Alcoholic Fatty Liver Disease (NAFLD)