2026-08-05T11:42:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/237462024-11-29T00:40:30Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Sharifi-Rad, Javad
author
Seidel, Veronique
author
Izabela, Michalak
author
Monserrat-Mesquida, Margalida
author
Sureda Gomila, Antoni
author
Ormazabal, Valeska
author
Zuniga, Felipe A
author
Mangalpady, Shivaprasad Shetty
author
Pezzani, Raffaele
author
Ydyrys, Alibek
author
Tussupbekova, Gulmira
author
Martorell, Miquel
author
Calina, Daniela
author
Cho, William C
2024-10-09T06:35:33Z
2024-10-09T06:35:33Z
2023-05-01
Sharifi-Rad J, Seidel V, Izabela M, Monserrat-Mequida M, Sureda A, Ormazabal V, et al. Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy. Cell Commun Signal. 2023 May 1;21(1):89.
10.1186/s12964-023-01109-0
1478-811X
Cell communication and signaling : CCS
https://hdl.handle.net/20.500.13003/18953
37127651
L2023012224
2-s2.0-85157976201
https://hdl.handle.net/20.500.12105/23746
981359100004
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. Video Abstract.
eng
Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
research article