2026-05-17T01:18:40Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/237462024-11-29T00:40:30Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Sharifi-Rad, Javad author Seidel, Veronique author Izabela, Michalak author Monserrat-Mesquida, Margalida author Sureda Gomila, Antoni author Ormazabal, Valeska author Zuniga, Felipe A author Mangalpady, Shivaprasad Shetty author Pezzani, Raffaele author Ydyrys, Alibek author Tussupbekova, Gulmira author Martorell, Miquel author Calina, Daniela author Cho, William C author 2023-05-01 Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. Video Abstract. Sharifi-Rad J, Seidel V, Izabela M, Monserrat-Mequida M, Sureda A, Ormazabal V, et al. Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy. Cell Commun Signal. 2023 May 1;21(1):89. 10.1186/s12964-023-01109-0 1478-811X Cell communication and signaling : CCS https://hdl.handle.net/20.500.13003/18953 37127651 L2023012224 2-s2.0-85157976201 https://hdl.handle.net/20.500.12105/23746 981359100004 Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy