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00925njm 22002777a 4500 dc Callejón-Leblic, Belén author Sánchez Espirilla, Saida author Gotera-Rivera, Carolina author Santana, Rafael author Díaz-Olivares, Isabel author Marín, José M author Casanova Macario, Ciro author García-Cosío, Borja author Fuster Gomila, Antonia author Solanes-Garcia, Ingrid author de-Torres, Juan P author Feu Collado, Nuria author Cabrera Lopez, Carlos author Amado Diago, Carlos author Romero Plaza, Amparo author Padrón Fraysse, Luis Alejandro author Márquez Martín, Eduardo author Marín Royo, Margarita author Balcells Vilarnau, Eva author Llunell Casanovas, Antonia author Martínez González, Cristina author Galdíz Iturri, Juan Bautista author Lacárcel Bautista, Celia author Gómez-Ariza, José Luis author Pereira-Vega, Antonio author Seijo, Luis author Lopez-Campos, Jose Luis author Peces-Barba, Germán author García-Barrera, Tamara author 2023-09-18 Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC. Callejón-Leblic B, Sánchez Espirilla S, Gotera-Rivera C, Santana R, Díaz-Olivares I, Marín JM, et al. Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease. Int J Mol Sci. 2023 Sep 18;24(18):14250. 10.3390/ijms241814250 1422-0067 International journal of molecular sciences https://hdl.handle.net/20.500.13003/19943 37762552 L2025765213 2-s2.0-85172917411 https://hdl.handle.net/20.500.12105/23714 1071815200001 Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease