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oai:repisalud.isciii.es:20.500.12105/237092024-11-28T20:47:01Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Fernández-Billón, María author Llambías-Cabot, Aina E author Jordana-Lluch, Elena author Oliver, Antonio author Macià, Maria Dolores author 2023-12 Pseudomonas aeruginosa is a major cause of life-threatening acute infections and life-long lasting chronic infections. The characteristic biofilm mode of life in P. aeruginosa chronic infections severely limits the efficacy of antimicrobial therapies, as it leads to intrinsic tolerance, involving physical and physiological factors in addition to biofilm-specific genes that can confer a transient protection against antibiotics promoting the development of resistance. Indeed, a striking feature of this pathogen is the extraordinary capacity to develop resistance to nearly all available antibiotics through the selection of chromosomal mutations, evidenced by its outstanding and versatile mutational resistome. This threat is dramatically amplified in chronic infections, driven by the frequent emergence of mutator variants with enhanced spontaneous mutation rates. Thus, this mini review is focused on describing the complex interplay of antibiotic resistance mechanisms in P. aeruginosa biofilms, to provide potentially useful information for the design of effective therapeutic strategies. Fernández-Billón M, Llambías-Cabot AE, Jordana-Lluch E, Oliver A, Macià MD. Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms. Biofilm. 2023 Dec;5:100129. 10.1016/j.bioflm.2023.100129 2590-2075 Biofilm https://hdl.handle.net/20.500.13003/19000 37205903 https://hdl.handle.net/20.500.12105/23709 Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms