2026-04-29T12:23:01Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/237062024-11-28T21:38:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Parvanova, Aneliya author Abbate, Manuela author Yañez, Aina M author Bennasar-Veny, Miquel author López-González, Angel Arturo author Ramírez-Manent, José Ignacio author Iliev, Ilian Petrov author Fresneda, Sergio author Arias-Fernández, María author Remuzzi, Giuseppe author Ruggenenti, Piero author 2023-05-23 Aims: To investigate the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) in prediabetes, visceral obesity, and preserved kidney function, and explore whether MAFLD is associated with hyperfiltration. Methods: We analyzed data from 6697 Spanish civil servants, aged 18-65 years, with fasting plasma glucose ≥ 100 and ≤ 125 mg/dL (prediabetes, ADA), waist circumference ≥ 94 cm in men and ≥ 80 cm in women (visceral obesity, IDF) and de-indexed estimated glomerular filtration rate (eGFR) ≥ 60 ml/min, collected during occupational health visits. The association between MAFLD and hyperfiltration (eGFR > age- and sex-specific 95th percentile) was tested by multivariable logistic regression analyses. Results: Overall, 4213 patients (62.9%) had MAFLD, and 330 (4.9%) were hyperfiltering. MAFLD was more frequent in hyperfiltering than in non-hyperfiltering subjects (86.4% vs 61.7%, P < 0.001). BMI, waist circumference, systolic, diastolic, mean arterial pressure, and prevalence of hypertension were higher in hyperfiltering than in non-hyperfiltering subjects (P < 0.05). MAFLD was independently associated with hyperfiltration, even after adjusting for common confounders [OR (95% CI): 3.36 (2.33-4.84), P < 0.001]. In stratified analyses MAFLD potentiated age-related eGFR decline vs. non-MAFLD (P < 0.001). Conclusions: More than half of subjects with prediabetes, visceral obesity and eGFR ≥ 60 ml/min presented MAFLD that was associated with hyperfiltration and potentiated the age-related eGFR decline. Parvanova A, Abbate M, Yañez AM, Bennasar-Veny M, López-González ÁA, Ramírez-Manent JI, et al. MAFLD and glomerular hyperfiltration in subjects with prediabetes, visceral obesity and preserved kidney function: A cross-sectional study. Diabetes Res Clin Pract. 2023 May 23;201:110729. 10.1016/j.diabres.2023.110729 1872-8227 Diabetes research and clinical practice https://hdl.handle.net/20.500.13003/18992 37230296 L2024693682 2-s2.0-85160266340 https://hdl.handle.net/20.500.12105/23706 1013316700001 MAFLD and glomerular hyperfiltration in subjects with prediabetes, visceral obesity and "preserved" kidney function: A cross-sectional study