2026-05-20T04:01:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/236822024-11-28T16:52:13Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16958col_20.500.12105_16960col_20.500.12105_16962col_20.500.12105_16967col_20.500.12105_16972
Repisalud
author
Escrihuela-Vidal, Francesc
author
Kaasch, Achim J
author
Von Cube, Maja
author
Rieg, Siegbert
author
Kern, Winfried V
author
Seifert, Harald
author
Song, Kyoung-Ho
author
Liao, Chun-Hsing
author
Tilley, Robert
author
Gott, Hannah
author
Scarborough, Matt
author
Gordon, Claire
author
Llewelyn, Martin J
author
Kuehl, Richard
author
Morata, Laura
author
Soriano, Alex
author
Edgeworth, Jonathan
author
Ruiz de Gopegui-Bordes, Enrique
author
Nsutebu, Emmanuel
author
Cisneros, José Miguel
author
Fowler, Vance G.
author
Thwaites, Guy
author
López-Contreras, Joaquín
author
Barlow, Gavin
author
Ternavasio-De La Vega, Hugo Guillermo
author
Rodriguez-Bano, Jesus
author
Lopez-Cortes, Luis Eduardo
2024-10-09T06:35:02Z
2024-10-09T06:35:02Z
2023-04
Escrihuela-Vidal F, Kaasch AJ, Von Cube M, Rieg S, Kern W V, Seifert H, et al. Impact of adherence to individual quality-of-care indicators on the prognosis of bloodstream infection due to Staphylococcus aureus: a prospective observational multicentre cohort. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2022 Oct;
10.1016/j.cmi.2022.10.019
1469-0691
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
https://hdl.handle.net/20.500.13003/18860
36283610
L2021159185
2-s2.0-85141779057
https://hdl.handle.net/20.500.12105/23682
996484100001
Objectives: To analyse the adherence and impact of quality-of-care indicators (QCIs) in the management of Staphylococcus aureus bloodstream infection in a prospective and multicentre cohort. Methods: Analysis of the prospective, multicentre international S. Aureus Collaboration cohort of S. Aureus bloodstream infection cases observed between January 2013 and April 2015. Multivariable analysis was performed to evaluate the impact of adherence to QCIs on 90-day mortality. Results: A total of 1784 cases were included. Overall, 90-day mortality was 29.9% and mean follow-up period was 118 days. Adherence was 67% (n = 1180/1762) for follow-up blood cultures, 31% (n = 416/1342) for early focus control, 77.6% (n = 546/704) for performance of echocardiography, 75.5% (n = 1348/1784) for adequacy of targeted antimicrobial therapy, 88.6% (n = 851/960) for adequacy of treatment duration in non-complicated bloodstream infections and 61.2% (n = 366/598) in complicated bloodstream infections. Full bundle adherence was 18.4% (n = 328/1784). After controlling for immortal time bias and potential confounders, focus control (adjusted hazard ratio = 0.76; 95% CI, 0.59-0.99; p 0.038) and adequate targeted antimicrobial therapy (adjusted hazard ratio = 0.75; 95% CI, 0.61-0.91; p 0.004) were associated with low 90-day mortality. Discussion: Adherence to QCIs in S. Aureus bloodstream infection did not reach expected rates. Apart from the benefits of application as a bundle, focus control and adequate targeted therapy were independently associated with low mortality.
eng
Impact of adherence to individual quality-of-care indicators on the prognosis of bloodstream infection due to Staphylococcus aureus: a prospective observational multicentre cohort
research article