2026-05-22T16:34:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/236742025-05-08T17:19:57Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16983
Repisalud
author
Bullón-Vela, Vanessa
author
Xu, Yifan
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Razquin, Cristina
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Abete, Itziar
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Zulet, Maria Angeles
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Martínez-González, Miguel A
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Buil-Corsiales, Pilar
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Vitelli-Storelli, Facundo
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Martín Sánchez, Vicente
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Vazquez-Ruiz, Zenaida
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Sayon-Orea, Carmen
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Domínguez-Fernández, Maite
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Cid, Concepción
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Estruch, Ramon
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Lamuela-Raventós, Rosa María
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Fito, Montserrat
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Blanchart, Gemma
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Babio, Nancy
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Salas-Salvado, Jordi
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Tinahones, Francisco J
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Tur, Josep A
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Romaguera, Dora
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Konieczna, Jadwiga
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Pintó, Xavier
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Daimiel, Lidia
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Rodriguez-Mateos, Ana
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Martínez, José Alfredo
2024-10-09T06:35:01Z
2024-10-09T06:35:01Z
2023-01-23
Bullón-Vela V, Xu Y, Razquin C, Abete I, Zulet MA, Martínez-González MA, et al. Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites. Food Funct. 2023;14(2):1011-23.
10.1039/d2fo02846h
2042-650X
Food & function
https://hdl.handle.net/20.500.13003/18687
36562455
L639850291
2-s2.0-85144960321
https://hdl.handle.net/20.500.12105/23674
903073700001
Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.
eng
Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites
research article