2026-07-16T12:36:07Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/236722024-11-29T02:27:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Stojnic, Bojan author Galmés, Sebastià author Serrano, Alba author Sulli, Maria author Sušak, Lana author Seye, Ndioba author Palou, Andreu author Diretto, Gianfranco author Bonet, M Luisa author Ribot, Joan author 2023-12-08 Glycosaminoglycans are complex carbohydrates used as nutraceuticals for diverse applications. We studied the potential of the glycosaminoglycan dermatan sulfate (DS) to counteract the development of diet-induced obesity (DIO) using obesity-prone mice fed a high-fat diet (HFD) as a model. Oral DS supplementation protected the animals against HFD-induced increases in whole-body adiposity, visceral fat mass, adipocyte size, blood glucose levels, insulin resistance, and pro-inflammatory lipids levels in brown adipose tissue (BAT) and the liver, where it largely counteracted the HFD-induced changes in the nonpolar metabolome. Protection against DIO in the DS-supplemented mice occurred despite higher energy intake and appeared to be associated with increased energy expenditure, higher uncoupling protein 1 expression in BAT, decreased BAT "whitening," and an enhanced channeling of fuel substrates toward skeletal muscle. This work is the first preclinical study to examine the anti-obesity activity of DS tested individually in vivo. The results support possible uses of DS as an active component in functional foods/supplements to manage obesity and associated metabolic diseases. Stojnic B, Galmés S, Serrano A, Sulli M, Sušak, L, Seye N, et al. Glycosaminoglycan dermatan sulfate supplementation decreases diet-induced obesity and metabolic dysfunction in mice. Biofactors. 2023 Dec. 10.1002/biof.2022 1872-8081 BioFactors (Oxford, England) https://hdl.handle.net/20.500.13003/20192 38063391 L2026990531 2-s2.0-85179368380 https://hdl.handle.net/20.500.12105/23672 1116444400001 Glycosaminoglycan dermatan sulfate supplementation decreases diet-induced obesity and metabolic dysfunction in mice