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oai:repisalud.isciii.es:20.500.12105/236662024-11-28T20:42:03Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Amengual-Tugores, Andreu Miquel author Ráez-Meseguer, Carmen author Forteza-Genestra, Maria Antónia author Monjo, Marta author Ramis, Joana Maria author 2023-02-18 Hydrogels and extracellular vesicle-based therapies have been proposed as emerging therapeutic assets in wound closure. The combination of these elements has given good results in managing chronic and acute wounds. The intrinsic characteristics of the hydrogels in which the extracellular vesicles (EVs) are loaded allow for overcoming barriers, such as the sustained and controlled release of EVs and the maintenance of the pH for their conservation. In addition, EVs can be obtained from different sources and through several isolation methods. However, some barriers must be overcome to transfer this type of therapy to the clinic, for example, the production of hydrogels containing functional EVs and identifying long-term storage conditions for EVs. The aim of this review is to describe the reported EV-based hydrogel combinations, along with the obtained results, and analyze future perspectives. Amengual-Tugores AM, Ráez-Meseguer C, Forteza-Genestra MA, Monjo M, Ramis JM. Extracellular Vesicle-Based Hydrogels for Wound Healing Applications. Int J Mol Sci. 2023 Feb 18;24(4):4104. https://hdl.handle.net/20.500.13003/18921 https://hdl.handle.net/20.500.12105/23666 36835516 10.3390/ijms24044104 1422-0067 International journal of molecular sciences 2-s2.0-85149053727 944992800001 L2021826258 Extracellular Vesicle-Based Hydrogels for Wound Healing Applications