2026-04-29T06:16:06Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/236542024-11-29T00:56:19Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author García-Gasalla, Mercedes author Berman-Riu, Maria author Rodríguez, Adrián author Iglesias, Amanda author Fraile-Ribot, Pablo author Toledo Pons, Nuria author Pol-Pol, Elisabet author Ferré Beltrán, Adrián author Artigues Serra, Francisca author Martin Pena, Maria Luisa author Pons De Ves, Jaime author Murillas Angoiti, Javier author Oliver, Antonio author Riera, Melchor author Ferrer Balaguer, Juana Maria 2024-10-09T06:34:11Z 2024-10-09T06:34:11Z 2023-09 Garcia-Gasalla M, Berman-Riu M, Rodriguez A, Iglesias A, Fraile-Ribot PA, Toledo-Pons N, et al. Elevated complement C3 and increased CD8 and type 1 helper lymphocyte T populations in patients with post-COVID-19 condition. Cytokine. 2023 Sep;169:156295. https://hdl.handle.net/20.500.13003/19378 https://hdl.handle.net/20.500.12105/23654 37453328 10.1016/j.cyto.2023.156295 1096-0023 Cytokine 2-s2.0-85165026253 1043760700001 L2025720741 Background: Biological markers associated to post-COVID-19 condition (PCC) have not been clearly identified. Methods: Eighty-two patients attending our post-COVID-19 outpatient clinic were recruited and classified as fully recovered (40.2%) or presenting with PCC (59.8%). Clinical and radiological data, laboratory markers, cytokines, and lymphocyte populations were analyzed. Results: Median number of days after hospitalization was 78.5 [p25-p75: 60-93] days. PCC was significantly more frequent in women, in patients with a previously critical COVID-19, and in those with two or more comorbidities. No differences were found in lymphocyte counts, ferritin, C-reactive protein, D-dimer or sCD25, IL-1β, IL-1Ra, IL-6, CXCL8, IL-17A, IL-18, IL-22, IFN-γ, TNF-α, and IL-10 cytokines levels. PCC patients showed significantly higher levels of complement factor C3 than fully recovered patients: median C3 128 mg/dL [p25-p75:107-135] vs 111 mg/dL [p25-p75: 100-125] (p =.005), respectively. In the flow cytometry assessment of peripheral blood lymphocyte subpopulations, PCC patients showed significantly increased CD8 populations compared to fully recovered patients: median CD8: 529 [p25-p75: 384-683] vs 370/mm3 [p25-p75:280-523], p =.007. When type 1, 2, 17/22, and 17.1 helper and follicular T lymphocyte subpopulations were analyzed, the frequency of Th1 was significantly higher in PCC patients compared to fully recovered patients (30% vs 38.5%, p =.028). Conclusion: Patients with a post-COVID-19 condition showed significantly increased immunological parameters of inflammation (complement factor C3 and CD8 and Th1 T lymphocyte populations) compared to fully recovered patients. These parameters could be used as biological markers of this condition. eng Elevated complement C3 and increased CD8 and type 1 helper lymphocyte T populations in patients with post-COVID-19 condition research article