2026-05-22T23:05:30Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/236512024-10-09T06:34:09Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16973

00925njm 22002777a 4500 dc Garcia, Aurora author Yáñez, Aina M author Bennasar-Veny, Miquel author Navarro, Capilla author Salva, Joan author Ibarra, Olga author Gomez-Juanes, Rocío author Serrano-Ripoll, Maria Jesus author Oliván, Bárbara author Gili, Margalida author Roca, Miquel author Riera-Serra, Pau author Aguilar-Latorre, Alejandra author Montero-Marin, Jesús author Garcia Toro, Mauro author 2023-01 Background: The high prevalence of depression is partly attributable to the poor response of patients to first-line antidepressants. Multimodal programs that promote a healthy lifestyle are successful in treating depression when used as a complementary therapy, but their medium- and long-term benefits have not been demonstrated for patients with treatment-resistant depression (TRD). The main aim of this study was to compare the effectiveness of a lifestyle modification program (LMP) with mindfulness-based cognitive therapy (MBCT) and a placebo-control (written suggestions for lifestyle changes) in Spanish patients with TRD. Methods: This controlled clinical trial randomized 94 patients with TRD into 3 arms. The primary outcome was the Beck Depression Inventory-II (BDI-II) score at baseline, 2, 6 and 12 months. The secondary outcomes were changes in scores that evaluated quality-of-life, adherence to the Mediterranean diet, physical activity, and social support. Results: Relative to the placebo group, the LMP and MBCT groups had significantly better quality of life (p = 0.017; p = 0.027), and the LMP group had significantly better adherence to the Mediterranean diet (p<0.001) and reduced use of antidepressants (p = 0.036). However, the three groups showed no significant differences in BDI-II score. Limitations: Only about half of the planned 180 patients were recruited, in part due to the COVID-19 pandemic. Conclusions: There was no evidence that the LMP treatment significantly reduced symptoms of depression relative to the other groups during the COVID-19 lockdown. Garcia A, Yáñez AM, Bennasar-Veny M, Navarro C, Salva J, Ibarra O, et al. Efficacy of an adjuvant non-face-to-face multimodal lifestyle modification program for patients with treatment-resistant major depression: A randomized controlled trial. Psychiatry Res. 2023 Jan;319:114975. 10.1016/j.psychres.2022.114975 1872-7123 Psychiatry research http://hdl.handle.net/20.500.13003/18551 36442318 L2019866790 https://hdl.handle.net/20.500.12105/23651 Efficacy of an adjuvant non-face-to-face multimodal lifestyle modification program for patients with treatment-resistant major depression: A randomized controlled trial