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00925njm 22002777a 4500 dc Donat-Vargas, Carolina author Mico, Víctor author San-Cristobal, Rodrigo author Martínez-González, Miguel Ángel author Salas-Salvado, Jordi author Corella, Dolores author Fitó, Montserrat author Alonso-Gómez, Ángel Maria author Wärnberg, Julia author Vioque, Jesus author Romaguera, Dora author López-Miranda, José author Estruch, Ramon author Damas-Fuentes, Miguel author Lapetra, José author Serra-Majem, Lluis author Bueno-Cavanillas, Aurora author Tur, Josep A author Cinza-Sanjurjo, Sergio author Pintó, Xavier author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Vidal, Josep author Causso, Claudia author Ros, Emilio author Toledo, Estefanía author Manzanares, Josep Maria author Ortega-Azorín, Carolina author Castañer, Olga author Peña-Orihuela, Patricia Judith author Zazo, Juan Manuel author Muñoz Bravo, Carlos author Martinez-Urbistondo, Diego author Chaplin, Alice author Casas, Rosa author Cano Ibáñez, Naomi author Tojal-Sierra, Lucas author Gómez-Perez, Ana María author Pascual Roquet-Jalmar, Elena author Mestre, Cristina author Barragán, Rocío author Schröder, Helmut author Garcia-Rios, Antonio author Candela García, Inmaculada author Ruiz-Canela, Miguel author Babio, Nancy author Malcampo, Mireia author Daimiel, Lidia author Martínez, Alfredo author 2023-10-19 Anemia causes hypo-oxygenation in the brain, which could lead to cognitive disorders. We examined dietary iron intake as well as anemia markers (i.e., hemoglobin, hematocrit, mean corpuscular volume) and diabetes coexistence in relation to neuropsychological function and quality of life. In this study, 6117 community-dwelling adults aged 55-75 years (men) and 60-75 years (women) with overweight/obesity and metabolic syndrome were involved. We performed the Mini-Mental State Examination (MMSE), the Trail Making Test parts A and B (TMT-A/B), Semantic Verbal Fluency of animals (VFT-a), Phonological Verbal Fluency of letter P (VFT-p), Digit Span Test (DST), the Clock Drawing Test (CDT), and the Short Form-36 Health Survey (SF36-HRQL test). Dietary iron intake did not influence neuropsychological function or quality of life. However, anemia and lower levels of anemia markers were associated with worse scores in all neurophysiological and SF36-HRQL tests overall, but were especially clear in the MMSE, TMT-B (cognitive flexibility), and the physical component of the SF36-HRQL test. The relationships between anemia and diminished performance in the TMT-A/B and VFT tasks were notably pronounced and statistically significant solely among participants with diabetes. In brief, anemia and reduced levels of anemia markers were linked to inferior cognitive function, worse scores in different domains of executive function, as well as a poorer physical, but not mental, component of quality of life. It was also suggested that the coexistence of diabetes in anemic patients may exacerbate this negative impact on cognition. Nevertheless, dietary iron intake showed no correlation with any of the outcomes. To make conclusive recommendations for clinical practice, our findings need to be thoroughly tested through methodologically rigorous studies that minimize the risk of reverse causality. Donat-Vargas C, Mico V, San-Cristobal R, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk. Nutrients. 2023 Oct 19;15(20):4440. 10.3390/nu15204440 2072-6643 Nutrients https://hdl.handle.net/20.500.13003/20006 37892515 L2026379122 2-s2.0-85175272652 https://hdl.handle.net/20.500.12105/23636 Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk