2026-06-14T03:30:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/236342024-11-28T14:53:28Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16959col_20.500.12105_16961col_20.500.12105_16962col_20.500.12105_16966col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16969col_20.500.12105_16977col_20.500.12105_16982col_20.500.12105_16983col_20.500.12105_16989
Repisalud
author
Khoury, Nadine
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Martínez, María Ángeles
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Paz-Graniel, Indira
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Martínez-González, Miguel Ángel
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Corella, Dolores
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Castañer, Olga
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Martínez, J Alfredo
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Alonso-Gómez, Ángel M
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Wärnberg, Julia
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Vioque, Jesus
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Romaguera, Dora
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López-Miranda, José
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Estruch, Ramon
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Tinahones, Francisco J
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Lapetra, José
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Serra-Majem, Lluis
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Bueno-Cavanillas, Aurora
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Tur, Josep A
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Sanjurjo, Sergio Cinza
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Pintó, Xavier
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Gaforio, José Juan
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Matía-Martín, Pilar
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Vidal, Josep
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Vazquez, Clotilde
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Daimiel, Lidia
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Ros, Emilio
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Sayon-Orea, Carmen
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Sorli, Jose V.
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Pérez-Vega, Karla-Alejandra
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Garcia-Rios, Antonio
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Bellvert, Nuria Gómez
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Gómez-Gracia, Enrique
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Zulet, MA
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Chaplin, Alice
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Casas, Rosa
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Salcedo-Bellido, Inmaculada
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Tojal-Sierra, Lucas
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Rosa Bernal-Lopez, Maria
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Vazquez-Ruiz, Zenaida
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Asensio, Eva M
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Goday, Albert
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Peña-Orihuela, Patricia J
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Signes-Pastor, Antonio J
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Garcia-Arellano, Ana
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Fito, Montserrat
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Babio, Nancy
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Salas-Salvado, Jordi
2024-10-09T06:33:55Z
2024-10-09T06:33:55Z
2023-06-15
Khoury N, Martínez MÁ, Paz-Graniel I, Martínez-González MÁ, Corella D, Castañer O, et al. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status. Environ Res. 2023 Jun;227:115697.
10.1016/j.envres.2023.115697
1096-0953
Environmental research
https://hdl.handle.net/20.500.13003/18975
36972775
L2023596856
2-s2.0-85151281178
https://hdl.handle.net/20.500.12105/23634
970314500001
Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results.
eng
Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status
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