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00925njm 22002777a 4500 dc Khoury, Nadine author Martínez, María Ángeles author Paz-Graniel, Indira author Martínez-González, Miguel Ángel author Corella, Dolores author Castañer, Olga author Martínez, J Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesus author Romaguera, Dora author López-Miranda, José author Estruch, Ramon author Tinahones, Francisco J author Lapetra, José author Serra-Majem, Lluis author Bueno-Cavanillas, Aurora author Tur, Josep A author Sanjurjo, Sergio Cinza author Pintó, Xavier author Gaforio, José Juan author Matía-Martín, Pilar author Vidal, Josep author Vazquez, Clotilde author Daimiel, Lidia author Ros, Emilio author Sayon-Orea, Carmen author Sorli, Jose V. author Pérez-Vega, Karla-Alejandra author Garcia-Rios, Antonio author Bellvert, Nuria Gómez author Gómez-Gracia, Enrique author Zulet, MA author Chaplin, Alice author Casas, Rosa author Salcedo-Bellido, Inmaculada author Tojal-Sierra, Lucas author Rosa Bernal-Lopez, Maria author Vazquez-Ruiz, Zenaida author Asensio, Eva M author Goday, Albert author Peña-Orihuela, Patricia J author Signes-Pastor, Antonio J author Garcia-Arellano, Ana author Fito, Montserrat author Babio, Nancy author Salas-Salvado, Jordi author 2023-06-15 Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results. Khoury N, Martínez MÁ, Paz-Graniel I, Martínez-González MÁ, Corella D, Castañer O, et al. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status. Environ Res. 2023 Jun;227:115697. 10.1016/j.envres.2023.115697 1096-0953 Environmental research https://hdl.handle.net/20.500.13003/18975 36972775 L2023596856 2-s2.0-85151281178 https://hdl.handle.net/20.500.12105/23634 970314500001 Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status