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oai:repisalud.isciii.es:20.500.12105/236152024-11-29T04:36:13Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Capó Fiol, Xavier author Galmes-Panades, Aina Maria author Navas-Enamorado, Cayetano author Ortega-Moral, Ana author Marín, Silvia author Cascante, Marta author Sanchez-Polo, Andrés author Masmiquel Comas, Lluis author Torrens-Mas, Margalida author Gonzalez-Freire, Marta author 2023-08-13 This study aimed to assess the relationship between age-related changes in Neurofilament Light Chain (NFL), a marker of neuronal function, and various factors including muscle function, body composition, and metabolomic markers. The study included 40 participants, aged 20 to 85 years. NFL levels were measured, and muscle function, body composition, and metabolomic markers were assessed. NFL levels increased significantly with age, particularly in men. Negative correlations were found between NFL levels and measures of muscle function, such as grip strength, walking speed, and chair test performance, indicating a decline in muscle performance with increasing NFL. These associations were more pronounced in men. NFL levels also negatively correlated with muscle quality in men, as measured by 50 kHz phase angle. In terms of body composition, NFL was positively correlated with markers of fat mass and negatively correlated with markers of muscle mass, predominantly in men. Metabolomic analysis revealed significant associations between NFL levels and specific metabolites, with gender-dependent relationships observed. This study provides insights into the relationship between circulating serum NFL, muscle function, and aging. Our findings hint at circulating NFL as a potential early marker of age-associated neurodegenerative processes, especially in men. Capo X, Galmes-Panades AM, Navas-Enamorado C, Ortega-Moral A, Marín S, Cascante M, et al. Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women. Int J Mol Sci. 2023 Aug 13;24(16):12751. 10.3390/ijms241612751 1422-0067 International journal of molecular sciences https://hdl.handle.net/20.500.13003/20081 37628936 L2025091581 2-s2.0-85168713605 https://hdl.handle.net/20.500.12105/23615 1119102300001 Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women