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00925njm 22002777a 4500 dc Shyam, Sangeetha author García-Gavilán, Jesús Francisco author Paz-Graniel, Indira author Gaforio, José J author Martínez-González, Miguel Ángel author Corella, Dolores author Martínez, J Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesus author Romaguera, Dora author López-Miranda, José author Estruch, Ramon author Tinahones, Francisco J author Lapetra, José author Serra-Majem, Lluis author Bueno-Cavanillas, Aurora author Tur, Josep A author Sanchez, Vicente Martin author Pintó, Xavier author Matía-Martín, Pilar author Vidal, Josep author Vazquez, Clotilde author Daimiel, Lidia author Ros, Emilio author Fernandez-Aranda, Fernando author Nishi, Stephanie K author Garcia-Regata, Oscar author Toledo, Estefanía author Asensio, Eva M author Castañer, Olga author Garcia-Rios, Antonio author Torres-Collado, Laura author Gómez-Gracia, Enrique author Zulet, M Angeles author Goñi-Ruiz, Nuria author Casas, Rosa author Cano-Ibáñez, Naomi author Tojal-Sierra, Lucas author Gómez-Perez, A M author Sorli, Jose V author Cinza-Sanjurjo, Sergio author Martín-Peláez, Sandra author Peña-Orihuela, Patricia J author Oncina-Canovas, Alejandro author Perez-Araluce, Rafael author Zomeño, María Dolores author Chaplin, Alice author Delgado-Rodríguez, Miguel author Babio, Nancy author Fitó, Montserrat author Salas-Salvado, Jordi author 2023-10-13 Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring. Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Trial registration: This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870). Shyam S, García-Gavilán JF, Paz-Graniel I, Gaforio JJ, Martínez-González MÁ, Corella D, et al. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort. BMC Med. 2023 Oct 13;21(1):390. 10.1186/s12916-023-03079-z 1741-7015 BMC medicine https://hdl.handle.net/20.500.13003/20007 37833678 L2026077722 2-s2.0-85174245400 https://hdl.handle.net/20.500.12105/23594 1088480600001 Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort