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oai:repisalud.isciii.es:20.500.12105/235652025-12-18T13:00:39Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991
Repisalud author Gutmann, Clemens author Takov, Kaloyan author Burnap, Sean A author Singh, Bhawana author Ali, Hashim author Theofilatos, Konstantinos author Reed, Ella author Hasman, Maria author Nabeebaccus, Adam author Fish, Matthew author McPhail, Mark Jw author O'Gallagher, Kevin author Schmidt, Lukas E author Cassel, Christian author Rienks, Marieke author Yin, Xiaoke author Auzinger, Georg author Napoli, Salvatore author Mujib, Salma F author Trovato, Francesca author Sanderson, Barnaby author Merrick, Blair author Niazi, Umar author Saqi, Mansoor author Dimitrakopoulou, Konstantina author Fernández-Leiro, Rafael author Braun, Silke author Kronstein-Wiedemann, Romy author Doores, Katie J author Edgeworth, Jonathan D author Shah, Ajay M author Bornstein, Stefan R author Tonn, Torsten author Hayday, Adrian C author Giacca, Mauro author Shankar-Hari, Manu author Mayr, Manuel funder British Heart Foundation funder NHS Foundation Trust funder UK Research & Innovation (UKRI) funder Medical Research Council UK (MRC) funder Unión Europea. Comisión Europea. European Research Council (ERC) funder Unión Europea funder Leducq Foundation funder Wellcome Trust funder Cancer Research UK 2024-10-08T10:10:41Z 2024-10-08T10:10:41Z 2021-06-07 Nat Commun . 2021 Jun 7;12(1):3406. Nat Commun 34099652 https://hdl.handle.net/20.500.12105/23565 Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19). We obtained blood samples (n = 474) from hospitalized COVID-19 patients (n = 123), non-COVID-19 ICU sepsis patients (n = 25) and healthy controls (n = 30). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in plasma or serum (RNAemia) of COVID-19 ICU patients when neutralizing antibody response was low. RNAemia is associated with higher 28-day ICU mortality (hazard ratio [HR], 1.84 [95% CI, 1.22-2.77] adjusted for age and sex). RNAemia is comparable in performance to the best protein predictors. Mannose binding lectin 2 and pentraxin-3 (PTX3), two activators of the complement pathway of the innate immune system, are positively associated with mortality. Machine learning identified 'Age, RNAemia' and 'Age, PTX3' as the best binary signatures associated with 28-day ICU mortality. In longitudinal comparisons, COVID-19 ICU patients have a distinct proteomic trajectory associated with mortality, with recovery of many liver-derived proteins indicating survival. Finally, proteins of the complement system and galectin-3-binding protein (LGALS3BP) are identified as interaction partners of SARS-CoV-2 spike glycoprotein. LGALS3BP overexpression inhibits spike-pseudoparticle uptake and spike-induced cell-cell fusion in vitro. eng MANNOSE-BINDING LECTIN INTERNATIONAL CONSENSUS DEFINITIONS HEPARAN-SULFATE PROTEOGLYCANS LONG PENTRAXIN PTX3 SEPTIC SHOCK SEPSIS DISEASE GLYCOPROTEIN INHIBITION ACTIVATION SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care. research article 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 URL https://repisalud.isciii.es/bitstreams/05bf68ea-1f6d-4008-a476-7bf639a2eeff/download File MD5 b719309f84f2da968c6d4b1db23c404c 7929694 application/pdf SARS-CoV-2rnaemia_2021.pdf URL https://repisalud.isciii.es/bitstreams/5559aa4a-9a30-47a3-a189-9e23f51089a5/download File MD5 95f6bf754ee3a5d6b5b0fcb2fcb27ba9 11271244 application/pdf 41467_2021_23494_MOESM1_ESM.pdf URL https://repisalud.isciii.es/bitstreams/c5948564-8de1-478b-af48-a113752f6e09/download File MD5 162bf134d1a390c78cb1ba86954b4e0b 1877307 application/pdf 41467_2021_23494_MOESM2_ESM.pdf URL https://repisalud.isciii.es/bitstreams/5b7dc801-0754-413f-a390-24412e0e23f0/download File MD5 9dcfaa779f2ea5ffa20f768191926b56 1596661 application/pdf 41467_2021_23494_MOESM3_ESM.pdf URL https://repisalud.isciii.es/bitstreams/9f36d451-b42b-4a5c-a2e7-a1f4dc2965d8/download File MD5 faf85d8b72d216c27e675859cbc6503c 100493 text/plain SARS-CoV-2rnaemia_2021.pdf.txt URL https://repisalud.isciii.es/bitstreams/bb260dea-09d8-43aa-9615-884b1d79bcd6/download File MD5 3fd61a0a84a22ed6722623c29e39caa5 37774 text/plain 41467_2021_23494_MOESM1_ESM.pdf.txt URL https://repisalud.isciii.es/bitstreams/790d1f48-d16e-4eee-b725-b1d0f77ceb99/download File MD5 15c4c0ccb5732c168ec725c95ce3ae0c 100349 text/plain 41467_2021_23494_MOESM2_ESM.pdf.txt URL https://repisalud.isciii.es/bitstreams/b4f88b05-5f5b-4aa0-bc22-8b81bedaff44/download File MD5 6ae36069629e91053c5ff50156b909e7 3286 text/plain 41467_2021_23494_MOESM3_ESM.pdf.txt