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oai:repisalud.isciii.es:20.500.12105/235652025-12-18T13:00:39Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991

00925njm 22002777a 4500 dc Gutmann, Clemens author Takov, Kaloyan author Burnap, Sean A author Singh, Bhawana author Ali, Hashim author Theofilatos, Konstantinos author Reed, Ella author Hasman, Maria author Nabeebaccus, Adam author Fish, Matthew author McPhail, Mark Jw author O'Gallagher, Kevin author Schmidt, Lukas E author Cassel, Christian author Rienks, Marieke author Yin, Xiaoke author Auzinger, Georg author Napoli, Salvatore author Mujib, Salma F author Trovato, Francesca author Sanderson, Barnaby author Merrick, Blair author Niazi, Umar author Saqi, Mansoor author Dimitrakopoulou, Konstantina author Fernández-Leiro, Rafael author Braun, Silke author Kronstein-Wiedemann, Romy author Doores, Katie J author Edgeworth, Jonathan D author Shah, Ajay M author Bornstein, Stefan R author Tonn, Torsten author Hayday, Adrian C author Giacca, Mauro author Shankar-Hari, Manu author Mayr, Manuel author 2021-06-07 Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19). We obtained blood samples (n = 474) from hospitalized COVID-19 patients (n = 123), non-COVID-19 ICU sepsis patients (n = 25) and healthy controls (n = 30). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in plasma or serum (RNAemia) of COVID-19 ICU patients when neutralizing antibody response was low. RNAemia is associated with higher 28-day ICU mortality (hazard ratio [HR], 1.84 [95% CI, 1.22-2.77] adjusted for age and sex). RNAemia is comparable in performance to the best protein predictors. Mannose binding lectin 2 and pentraxin-3 (PTX3), two activators of the complement pathway of the innate immune system, are positively associated with mortality. Machine learning identified 'Age, RNAemia' and 'Age, PTX3' as the best binary signatures associated with 28-day ICU mortality. In longitudinal comparisons, COVID-19 ICU patients have a distinct proteomic trajectory associated with mortality, with recovery of many liver-derived proteins indicating survival. Finally, proteins of the complement system and galectin-3-binding protein (LGALS3BP) are identified as interaction partners of SARS-CoV-2 spike glycoprotein. LGALS3BP overexpression inhibits spike-pseudoparticle uptake and spike-induced cell-cell fusion in vitro. Nat Commun . 2021 Jun 7;12(1):3406. Nat Commun 34099652 https://hdl.handle.net/20.500.12105/23565 MANNOSE-BINDING LECTIN INTERNATIONAL CONSENSUS DEFINITIONS HEPARAN-SULFATE PROTEOGLYCANS LONG PENTRAXIN PTX3 SEPTIC SHOCK SEPSIS DISEASE GLYCOPROTEIN INHIBITION ACTIVATION SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care.