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oai:repisalud.isciii.es:20.500.12105/235342024-11-28T19:18:42Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16963col_20.500.12105_16967
Repisalud author Serednytskyy, Oleksandr author Alonso-Fernandez, Alberto author Ribot Quetglas, Caterina author Herranz Mochales, Andrea author Álvarez Valdivielso, Ainhoa author Sanchez, Andres author Rodriguez, Paula author Gil, Ana V author Pia, Carla author Cubero, Jose P author Barcelo, Maria author Cerda Moncadas, Maria author Codina Marcet, Mercedes author Pena, Monica D author Barceló Bennasar, Antonia author Iglesias, Amanda author Morell Garcia, Daniel author Pena, Jose A author Gimenez, Maria P author Pinas, Maria C author Garcia-Rio, Francisco 2024-10-04T13:57:58Z 2024-10-04T13:57:58Z 2022-03-18 Serednytskyy O, Alonso-Fernandez A, Ribot C, Herranz A, Alvarez A, Sanchez A, et al. Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea. BMC Pulm Med. 2022 Mar 18;22(1):94. 10.1186/s12890-022-01888-1 1471-2466 BMC Pulmonary Medicine https://hdl.handle.net/20.500.13003/19842 35303833 L2015360659 2-s2.0-85126650324 https://hdl.handle.net/20.500.12105/23534 770623700002 Background: Although some evidence suggests an association between obstructive sleep apnea (OSA) and gestational diabetes mellitus (GDM), its consequences still remain largely unknown. We sought to determine whether OSA is associated with higher inflammation and sympathetic levels in GDM, and to relate them with insulin resistance and perinatal outcomes. Methods: OSA was identified by polysomnography and defined as an apnea-hypopnea index of ≥ 5 h-1. Plasma cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-10), metanephrine, and normetanephrine were determined by immunoassays. Results: We included 17 patients with GDM and OSA and 34 without OSA. Women with GDM and OSA had higher normetanephrine concentrations [81 IQR (59-134) vs. 68 (51-81) pg/mL]. No differences in the inflammatory profile were found, while IL-1β was higher in patients with mean nocturnal oxyhemoglobin saturation ≤ 94%. We found positive correlations between increased sympathetic activation and IL-1β, with obstructive apneas, while time in REM showed an inverse relationship with IL-1β and metanephrine. Furthermore, IL-10 was inversely related with time in sleep stages 1-2, and with the arousal index, and it was positively related with time in slow-wave sleep. Significant correlations were also found between IL-1β and insulin resistance. There were no significant differences in neonatal characteristics; however, we found inverse relationships between IL-10 and birth weight (BW), and percentile of BW. Conclusions: OSA increased sympathetic activity, and IL-1β concentration was higher in patients with GDM with lower nocturnal oxygenation, all of which were related with obstructive events, and time in REM. Moreover, IL-1β was related with insulin resistance, and IL-10 inversely correlated with neonatal BW. eng Gestational diabetes mellitus Fetal outcomes Cytokine inflammation Metanephrine Normetanephrine Obstructive sleep apnea Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea research article