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00925njm 22002777a 4500 dc García-Carrizo, Francisco author Galmés, Sebastià author Picó, Catalina author Palou, Andreu author Rodriguez, Ana María author 2022-10-19 Supplementation with the prebiotic pectin is associated with beneficial health effects. We aimed to characterize the cardioprotective actions of chronic high-esterified pectin (HEP) supplementation (10%) in a model of metabolic malprogramming in rats, prone to obesity and associated disorders: the progeny of mild calorie-restricted dams during the first half of pregnancy. Results show that pectin supplementation reverses metabolic malprogramming associated with gestational undernutrition. In this sense, HEP supplementation improved blood pressure, reduced heart lipid content, and regulated cardiac gene expression of atrial natriuretic peptide and lipid metabolism-related genes. Moreover, it caused an elevation in circulating levels of fibroblast growth factor 21 and a higher expression of its co-receptor β-klotho in the heart. Most effects are correlated with the gut levels of beneficial bacteria promoted by HEP. Therefore, chronic HEP supplementation shows cardioprotective actions, and hence, it is worth considering as a strategy to prevent programmed cardiometabolic alterations. García-Carrizo F, Galmés S, Picó C, Palou A, Rodríguez AM. Supplementation with the Prebiotic High-Esterified Pectin Improves Blood Pressure and Cardiovascular Risk Biomarker Profile, Counteracting Metabolic Malprogramming. J Agric Food Chem. 2022 Oct 19;70(41):13200-11. 10.1021/acs.jafc.2c03143 1520-5118 Journal of agricultural and food chemistry http://hdl.handle.net/20.500.13003/18511 36214580 L639224908 2-s2.0-85140272189 https://hdl.handle.net/20.500.12105/23530 868154200001 Supplementation with the Prebiotic High-Esterified Pectin Improves Blood Pressure and Cardiovascular Risk Biomarker Profile, Counteracting Metabolic Malprogramming