2026-05-14T15:19:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/235012024-11-28T18:14:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16962col_20.500.12105_16967col_20.500.12105_16971
Repisalud
author
Hernández-Rubio, Anna
author
Sanvisens, Arantza
author
Bolao, Ferran
author
Cachon-Suarez, Isabel
author
Garcia-Martin, Carme
author
Short, Antoni
author
Bataller, Ramon
author
Muga, Roberto
2024-10-04T13:46:28Z
2024-10-04T13:46:28Z
2022-02-16
Hernandez-Rubio A, Sanvisens A, Bolao F, Cachon-Suarez I, Garcia-Martin C, Short A, et al. Prevalence and associations of metabolic syndrome in patients with alcohol use disorder. Sci Rep. 2022 Feb 16;12(1):2625.
10.1038/s41598-022-06010-3
2045-2322
Scientific Reports
https://hdl.handle.net/20.500.13003/19766
35173187
L637282464
2-s2.0-85124777517
https://hdl.handle.net/20.500.12105/23501
757107700023
Excessive alcohol consumption has been associated with different components of the metabolic syndrome (MetS) such as arterial hypertension, dyslipidemia, type 2 diabetes or obesity. We aimed to analyze the prevalence and associations of MetS in patients with Alcohol Use Disorder (AUD). Cross-sectional study in heavy drinkers admitted for the treatment of AUD between 2013 and 2017. Medical comorbidity, anthropometric data, alcohol use and biological parameters were obtained. MetS was established according to the harmonized definition. A total of 728 patients (22% women) were included; median age was 47 years (IQR: 40-53.5), median alcohol consumption was 160 g/day (IQR: 115-240) and prevalence of MetS was 13.9%. The multivariate analysis showed a significant dose-response effect of estimated glomerular filtration (eGFR) and MetS: relative to patients with eGFR > 90 mL/min, those with eGFR (60-90 mL/min) and those with eGFR < 60 mL/min were 1.93 times (95% CI 1.18-3.15) and 5.61 times (95% CI 1.66-19.0) more likely to have MetS, respectively. MetS was significantly associated with hyperuricemia (OR 2.28, 95% CI 1.36-3.82) and elevated serum GGT (OR 3.67, 95% CI 1.80-7.46). Furthermore, for every increase of 1 year in age, the probability of MetS increased significantly (OR 1.03, 95% CI 1.01-1.05). MetS in heavy drinkers is independently associated with reduced kidney function and metabolic risk factors including hyperuricemia and elevated serum GGT.
eng
Prevalence and associations of metabolic syndrome in patients with alcohol use disorder
research article