2026-05-14T15:19:29Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/235012024-11-28T18:14:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16962col_20.500.12105_16967col_20.500.12105_16971

00925njm 22002777a 4500 dc Hernández-Rubio, Anna author Sanvisens, Arantza author Bolao, Ferran author Cachon-Suarez, Isabel author Garcia-Martin, Carme author Short, Antoni author Bataller, Ramon author Muga, Roberto author 2022-02-16 Excessive alcohol consumption has been associated with different components of the metabolic syndrome (MetS) such as arterial hypertension, dyslipidemia, type 2 diabetes or obesity. We aimed to analyze the prevalence and associations of MetS in patients with Alcohol Use Disorder (AUD). Cross-sectional study in heavy drinkers admitted for the treatment of AUD between 2013 and 2017. Medical comorbidity, anthropometric data, alcohol use and biological parameters were obtained. MetS was established according to the harmonized definition. A total of 728 patients (22% women) were included; median age was 47 years (IQR: 40-53.5), median alcohol consumption was 160 g/day (IQR: 115-240) and prevalence of MetS was 13.9%. The multivariate analysis showed a significant dose-response effect of estimated glomerular filtration (eGFR) and MetS: relative to patients with eGFR > 90 mL/min, those with eGFR (60-90 mL/min) and those with eGFR < 60 mL/min were 1.93 times (95% CI 1.18-3.15) and 5.61 times (95% CI 1.66-19.0) more likely to have MetS, respectively. MetS was significantly associated with hyperuricemia (OR 2.28, 95% CI 1.36-3.82) and elevated serum GGT (OR 3.67, 95% CI 1.80-7.46). Furthermore, for every increase of 1 year in age, the probability of MetS increased significantly (OR 1.03, 95% CI 1.01-1.05). MetS in heavy drinkers is independently associated with reduced kidney function and metabolic risk factors including hyperuricemia and elevated serum GGT. Hernandez-Rubio A, Sanvisens A, Bolao F, Cachon-Suarez I, Garcia-Martin C, Short A, et al. Prevalence and associations of metabolic syndrome in patients with alcohol use disorder. Sci Rep. 2022 Feb 16;12(1):2625. 10.1038/s41598-022-06010-3 2045-2322 Scientific Reports https://hdl.handle.net/20.500.13003/19766 35173187 L637282464 2-s2.0-85124777517 https://hdl.handle.net/20.500.12105/23501 757107700023 Prevalence and associations of metabolic syndrome in patients with alcohol use disorder