2026-04-29T04:09:19Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/234952024-10-04T13:46:25Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Quetglas-Llabrés, Magdalena author Quispe, Cristina author Herrera-Bravo, Jesús author Catarino, Marcelo D author Pereira, Olívia R author Cardoso, Susana M author Dua, Kamal author Chellappan, Dinesh Kumar author Pabreja, Kavita author Satija, Saurabh author Mehta, Meenu author Sureda, Antoni author Martorell, Miquel author Satmbekova, Dinara author Yeskaliyeva, Balakyz author Sharifi-Rad, Javad author Rasool, Naeem author Butnariu, Monica author Bagiu, Iulia Cristina author Bagiu, Radu Vasile author Calina, Daniela author Cho, William C author 2022 Bergapten (BP) or 5-methoxypsoralen (5-MOP) is a furocoumarin compound mainly found in bergamot essential oil but also in other citrus essential oils and grapefruit juice. This compound presents antibacterial, anti-inflammatory, hypolipemic, and anticancer effects and is successfully used as a photosensitizing agent. The present review focuses on the research evidence related to the therapeutic properties of bergapten collected in recent years. Many preclinical and in vitro studies have been evidenced the therapeutic action of BP; however, few clinical trials have been carried out to evaluate its efficacy. These clinical trials with BP are mainly focused on patients suffering from skin disorders such as psoriasis or vitiligo. In these trials, the administration of BP (oral or topical) combined with UV irradiation induces relevant lesion clearance rates. In addition, beneficial effects of bergamot extract were also observed in patients with altered serum lipid profiles and in people with nonalcoholic fatty liver. On the contrary, there are no clinical trials that investigate the possible effects on cancer. Although the bioavailability of BP is lower than that of its 8-methoxypsoralen (8-MOP) isomer, it has fewer side effects allowing higher concentrations to be administered. In conclusion, although the use of BP has therapeutic applications on skin disorders as a sensitizing agent and as components of bergamot extract as hypolipemic therapy, more trials are necessary to define the doses and treatment guidelines and its usefulness against other pathologies such as cancer or bacterial infections. Quetglas-Llabrés MM, Quispe C, Herrera-Bravo J, Catarino MD, Pereira OR, Cardoso SM, et al. Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects. Sun C, editor. Oxid Med Cell Longev. 25 apr 2022;2022:1-10. http://hdl.handle.net/20.500.13003/18079 https://hdl.handle.net/20.500.12105/23495 35509838 10.1155/2022/8615242 1942-0994 Oxidative medicine and cellular longevity 2-s2.0-85129383993 795953300009 L2018098774 Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects