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oai:repisalud.isciii.es:20.500.12105/234852024-10-04T13:46:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Sarubbo, Maria Fiorella author El Haji, Khaoulah author Vidal Balle, Aina author Bargay Lleonart, Joan author 2022-02 Due to the infection by the SARS-CoV-2 virus (COVID-19) there were also reported neurological symptoms, being the most frequent and best cited those that affect the cerebrovascular, sensorial, cognitive and motor functions, together with the neurological diffuse symptoms as for examples headache or dizziness. Besides, some of them behave high risk of mortality. Consequently, it is crucial to elucidate the mechanisms of action in brain of SARS-CoV-2 virus in order to create new therapeutic targets to fight against this new disease. Since now the mechanisms of arrival to the brain seems to be related with the following processes: blood brain barrier (BBB) disruption together with nervous or axonal transport of the virus by the trigeminal nerve, the vagus nerve, or the brain-gut-axis. Being two the mechanisms of brain affectation most cited: a direct affectation of the virus in the brain through neuroinvasion and an indirect mechanism of action due to the effects of the systemic infection. Both processes include the triggering of inflammation, hypoxia and the increased likelihood of secondary infections. This topic supposes a major novel challenge for neuroscience. Therefore, the aim of this review is to provide summarized information about the neurological symptomatology and the brain pathogenic mechanisms involved and reported in COVID-19. Sarubbo F, El Haji K, Vidal-Balle A, Bargay Lleonart J. Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience. Brain Behav Immun Health. 2022 Feb;19:100399. Epub 2021 Nov 30. 10.1016/j.bbih.2021.100399 2666-3546 Brain, Behavior, & Immunity - Health https://hdl.handle.net/20.500.13003/19711 34870247 L2015954428 https://hdl.handle.net/20.500.12105/23485 Brain COVID-19 Neuroinvasion Neurological symptoms Neuroscience SARS-CoV-2 Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience