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oai:repisalud.isciii.es:20.500.12105/234842024-11-29T07:00:42Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Sahebnasagh, Adeleh author Eghbali, Samira author Saghafi, Fatemeh author Sureda Gomila, Antoni author Avan, Razieh 2024-10-04T13:46:20Z 2024-10-04T13:46:20Z 2022-08-11 Sahebnasagh, Adeleh; Eghbali, Samira; Saghafi, Fatemeh; Sureda Gomila, Antoni; Avan, Razieh. Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases. Immun Ageing. 2022 Aug 11;19(1):36. 1742-4933 http://hdl.handle.net/20.500.13003/18178 https://hdl.handle.net/20.500.12105/23484 35953850 10.1186/s12979-022-00292-x Immunity & ageing : I & A 2-s2.0-85135818449 839670300001 L2018494291 The world population is progressively ageing, assuming an enormous social and health challenge. As the world ages, neurodegenerative diseases are on the rise. Regarding the progressive nature of these diseases, none of the neurodegenerative diseases are curable at date, and the existing treatments can only help relieve the symptoms or slow the progression. Recently, hormesis has increased attention in the treatment of age-related neurodegenerative diseases. The concept of hormesis refers to a biphasic dose-response phenomenon, where low levels of the drug or stress exert protective of beneficial effects and high doses deleterious or toxic effects. Neurohormesis, as the adaptive aspect of hormetic dose responses in neurons, has been shown to slow the onset of neurodegenerative diseases and reduce the damages caused by aging, stroke, and traumatic brain injury. Hormesis was also observed to modulate anxiety, stress, pain, and the severity of seizure. Thus, neurohormesis can be considered as a potentially innovative approach in the treatment of neurodegenerative and other neurologic disorders. Herbal medicinal products and supplements are often considered health resources with many applications. The hormesis phenomenon in medicinal plants is valuable and several studies have shown that hormetic mechanisms of bioactive compounds can prevent or ameliorate the neurodegenerative pathogenesis in animal models of Alzheimer's and Parkinson's diseases. Moreover, the hormesis activity of phytochemicals has been evaluated in other neurological disorders such as Autism and Huntington's disease. In this review, the neurohormetic dose-response concept and the possible underlying neuroprotection mechanisms are discussed. Different neurohormetic phytochemicals used for the better management of neurodegenerative diseases, the rationale for using them, and the key findings of their studies are also reviewed. eng Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases research article