2026-06-14T03:45:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/234772024-11-29T04:25:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Escobar-Salom, Maria
author
Torrens, Gabriel
author
Jordana-Lluch, Elena
author
Oliver, Antonio
author
Juan, Carlos
2024-10-04T13:46:18Z
2024-10-04T13:46:18Z
2022-06
Escobar-Salom M, Torrens G, Jordana-Lluch E, Oliver A, Juan C. Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives. Biol Rev. 2022 Jun;97(3):1005-37.
10.1111/brv.12830
1469-185X
1464-7931
Biological Reviews
https://hdl.handle.net/20.500.13003/19679
35043558
2-s2.0-85122871232
https://hdl.handle.net/20.500.12105/23477
743755300001
Mammalian innate immunity employs several humoral 'weapons' that target the bacterial envelope. The threats posed by the multidrug-resistant 'ESKAPE' Gram-negative pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are forcing researchers to explore new therapeutic options, including the use of these immune elements. Here we review bacterial envelope-targeting (peptidoglycan and/or membrane-targeting) proteins/peptides of the mammalian immune system that are most likely to have therapeutic applications. Firstly we discuss their general features and protective activity against ESKAPE Gram-negatives in the host. We then gather, integrate, and discuss recent research on experimental therapeutics harnessing their bactericidal power, based on their exogenous administration and also on the discovery of bacterial and/or host targets that improve the performance of this endogenous immunity, as a novel therapeutic concept. We identify weak points and knowledge gaps in current research in this field and suggest areas for future work to obtain successful envelope-targeting therapeutic options to tackle the challenge of antimicrobial resistance.
eng
multidrug-resistant Gram-negatives
ESKAPE pathogens
bacterial envelope
cell wall
peptidoglycan
bacterial membranes
mammalian humoral innate immunity
lysozyme
peptidoglycan recognition proteins
cationic antimicrobial peptides
Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives
research article