2026-06-14T03:53:10Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/234772024-11-29T04:25:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Escobar-Salom, Maria author Torrens, Gabriel author Jordana-Lluch, Elena author Oliver, Antonio author Juan, Carlos author 2022-06 Mammalian innate immunity employs several humoral 'weapons' that target the bacterial envelope. The threats posed by the multidrug-resistant 'ESKAPE' Gram-negative pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are forcing researchers to explore new therapeutic options, including the use of these immune elements. Here we review bacterial envelope-targeting (peptidoglycan and/or membrane-targeting) proteins/peptides of the mammalian immune system that are most likely to have therapeutic applications. Firstly we discuss their general features and protective activity against ESKAPE Gram-negatives in the host. We then gather, integrate, and discuss recent research on experimental therapeutics harnessing their bactericidal power, based on their exogenous administration and also on the discovery of bacterial and/or host targets that improve the performance of this endogenous immunity, as a novel therapeutic concept. We identify weak points and knowledge gaps in current research in this field and suggest areas for future work to obtain successful envelope-targeting therapeutic options to tackle the challenge of antimicrobial resistance. Escobar-Salom M, Torrens G, Jordana-Lluch E, Oliver A, Juan C. Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives. Biol Rev. 2022 Jun;97(3):1005-37. 10.1111/brv.12830 1469-185X 1464-7931 Biological Reviews https://hdl.handle.net/20.500.13003/19679 35043558 2-s2.0-85122871232 https://hdl.handle.net/20.500.12105/23477 743755300001 multidrug-resistant Gram-negatives ESKAPE pathogens bacterial envelope cell wall peptidoglycan bacterial membranes mammalian humoral innate immunity lysozyme peptidoglycan recognition proteins cationic antimicrobial peptides Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives