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oai:repisalud.isciii.es:20.500.12105/234762024-11-28T19:59:09Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Martin-Calvo, Nerea author Goni, Leticia author Tur, Josep A author Martinez, J. Alfredo author 2022-01 In recent decades, the incidence of type 2 diabetes (T2D) has increased dramatically in children and adolescents, posing a real public health problem. Beyond unhealthy diets and sedentary lifestyles, growing evidence suggests that some perinatal factors, such as low birth weight (LBW), are associated with higher risk of T2D in adulthood. In this regard, it remains unclear whether the increased risk is already present in childhood and adolescence. We conducted a systematic review and meta-analysis to clarify the association of LBW or being small for gestational age (SGA) with insulin resistance in childhood and adolescence. The systematic review resulted in 28 individual studies, and those with the same outcome were included within two random-effects meta-analyses. Compared with children or adolescents born with adequate size for gestational age, those SGA had 2.33-fold higher risk of T2D (95% confidence interval [CI]: 1.05-5.17). Furthermore, LBW and being SGA were associated with 0.20 higher mean homeostasis model assessment of insulin resistance (HOMA-IR) values (95% CI: 0.02-0.38). Given the high prevalence of preterm babies, from a population perspective, these results may be of great importance as they point to the existence of a potentially vulnerable subgroup of children and adolescents that could benefit from screening tests and early preventive strategies. Martin-Calvo N, Goni L, Tur JA, Martinez JA. Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis. Obes Rev. 2022 Jan;23 Suppl 1:e13380. 10.1111/obr.13380 1467-789X 1467-7881 Obesity Reviews https://hdl.handle.net/20.500.13003/19673 34786817 L2014198288 2-s2.0-85118492907 https://hdl.handle.net/20.500.12105/23476 719151700001 insulin resistance low birth weight small for gestational age STOP project Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis