2026-04-29T22:57:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/234742024-10-04T13:46:18Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Ruggenenti, Piero
author
Cortinovis, Monica
author
Trillini, Matias
author
Parvanova, Aneliya
author
Abbate, Manuela
author
Satriano, Chiara
author
Salvetti, Ferdinando
author
Bossi, Antonio C
author
Trevisan, Roberto
author
Perna, Annalisa
author
Peracchi, Tobia
author
Rubis, Nadia
author
Diadei, Olimpia
author
Martinetti, Davide
author
Gaspari, Flavio
author
Fontana, Luigi
author
Remuzzi, Giuseppe
author
CRESO 2 Study Organization
2024-10-04T13:46:18Z
2024-10-04T13:46:18Z
2022-03
Ruggenenti P, Cortinovis M, Trillini M, Parvanova A, Abbate M, Satriano C, et al. Long-term kidney and systemic effects of calorie restriction in overweight or obese type 2 diabetic patients (C.Re.S.O. 2 randomized controlled trial). Diabetes Res Clin Pract. 2022 Mar;185:109804. Epub 2022 Feb 24.
10.1016/j.diabres.2022.109804
1872-8227
Diabetes Research and Clinical Practice
https://hdl.handle.net/20.500.13003/19669
35219762
L2017098851
2-s2.0-85125557637
https://hdl.handle.net/20.500.12105/23474
810140100004
Aims: In type 2 diabetic patients with obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and is ameliorated by calorie restriction (CR). We assessed whether CR-induced amelioration of hyperfiltration could translate into slower long-term GFR decline in this population. Methods: In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded endpoint trial, consenting >40-year-old patients with type 2 diabetes, BMI ≥27 kg/m2, creatinine <1.2 mg/dL and albuminuria ≤300 mg/24 h were randomized (1:1) to two-year 25% CR (n = 53) or standard diet (SD, n = 50). Primary outcome was 6-month measured GFR. Analyses were by modified intention-to-treat. Results: At 6 months GFR decreased by 5.16 ± 10.03 mL/min (P = 0.001) with CR, and by 0.98 ± 9.71 mL/min (P = 0.497) with SD. Between-group difference was significant (P = 0.044). GFR decline from 6 to 24 months was significant with SD (P < 0.01), but not with CR (P = 0.075). Between-group difference, however, was not significant (P = 0.414). Body weight, BMI, waist circumference, systolic blood pressure, HbA1c, blood glucose, serum triglycerides decreased and ApoA-I concentration increased with CR. No changes were observed with SD. Between-group differences were significant. CR was tolerated well. Conclusions: In obese type 2 diabetic patients, CR ameliorated glomerular hyperfiltration and several cardiovascular risk factors, and blunted long-term GFR decline. Trial registration: NCT01930136.
eng
Calorie restriction
Cardiovascular risk
Nephropathy
Obesity
Type 2 diabetes
Long-term kidney and systemic effects of calorie restriction in overweight or obese type 2 diabetic patients (C.Re.S.O. 2 randomized controlled trial)
research article