2026-05-22T00:06:03Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/234642024-11-29T01:56:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Chaplin, Alice
author
Rodriguez, Ramon Maria
author
Segura-Sampedro, Juan José
author
Ochogavía-Seguí, Aina
author
Romaguera, Dora
author
Barceló-Coblijn, Gwendolyn
2024-10-04T13:46:16Z
2024-10-04T13:46:16Z
2022-10-28
Chaplin A, Rodriguez RM, Segura-Sampedro JJ, Ochogavía-Seguí A, Romaguera D, Barceló-Coblijn G. Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link? Int J Mol Sci. 2022 Oct 28;23(21):13128.
10.3390/ijms232113128
1422-0067
International journal of molecular sciences
http://hdl.handle.net/20.500.13003/18461
36361914
L2020040760
2-s2.0-85141587756
https://hdl.handle.net/20.500.12105/23464
882297400001
Colorectal cancer (CRC) is a major health problem worldwide, with an estimated 1.9 million new cases and 915,880 deaths in 2020 alone. The etiology of CRC is complex and involves both genetic and lifestyle factors. Obesity is a major risk factor for CRC, and the mechanisms underlying this link are still unclear. However, the generalized inflammatory state of adipose tissue in obesity is thought to play a role in the association between CRC risk and development. Visceral adipose tissue (VAT) is a major source of proinflammatory cytokines and other factors that contribute to the characteristic systemic low-grade inflammation associated with obesity. VAT is also closely associated with the tumor microenvironment (TME), and recent evidence suggests that adipocytes within the TME undergo phenotypic changes that contribute to tumor progression. In this review, we aim to summarize the current evidence linking obesity and CRC, with a focus on the role of VAT in tumor etiology and progression.
eng
Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?
research article