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oai:repisalud.isciii.es:20.500.12105/234642024-11-29T01:56:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Chaplin, Alice author Rodriguez, Ramon Maria author Segura-Sampedro, Juan José author Ochogavía-Seguí, Aina author Romaguera, Dora author Barceló-Coblijn, Gwendolyn author 2022-10-28 Colorectal cancer (CRC) is a major health problem worldwide, with an estimated 1.9 million new cases and 915,880 deaths in 2020 alone. The etiology of CRC is complex and involves both genetic and lifestyle factors. Obesity is a major risk factor for CRC, and the mechanisms underlying this link are still unclear. However, the generalized inflammatory state of adipose tissue in obesity is thought to play a role in the association between CRC risk and development. Visceral adipose tissue (VAT) is a major source of proinflammatory cytokines and other factors that contribute to the characteristic systemic low-grade inflammation associated with obesity. VAT is also closely associated with the tumor microenvironment (TME), and recent evidence suggests that adipocytes within the TME undergo phenotypic changes that contribute to tumor progression. In this review, we aim to summarize the current evidence linking obesity and CRC, with a focus on the role of VAT in tumor etiology and progression. Chaplin A, Rodriguez RM, Segura-Sampedro JJ, Ochogavía-Seguí A, Romaguera D, Barceló-Coblijn G. Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link? Int J Mol Sci. 2022 Oct 28;23(21):13128. 10.3390/ijms232113128 1422-0067 International journal of molecular sciences http://hdl.handle.net/20.500.13003/18461 36361914 L2020040760 2-s2.0-85141587756 https://hdl.handle.net/20.500.12105/23464 882297400001 Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?