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oai:repisalud.isciii.es:20.500.12105/234242024-10-04T13:22:46Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Cerón-Pisa, Noemi author Shafiek, Hanaa author Martín-Medina, Aina author Verdú, Javier author Jordana-Lluch, Elena author Escobar-Salom, Maria author Bover Barceló, Isabel author López-Causapé, Carla author Oliver, Antonio author Juan, Carlos author Iglesias, Amanda author García-Cosío, Borja 2024-10-04T13:22:46Z 2024-10-04T13:22:46Z 2022-07-23 Cerón-Pisa N, Shafiek H, Martín-Medina A, Verdú J, Jordana-Lluch E, Escobar-Salom M, et al. Effects of Inhaled Corticosteroids on the Innate Immunological Response to Pseudomonas aeruginosa Infection in Patients with COPD. Int J Mol Sci. 2022 Jul 23;23(15):8127. http://hdl.handle.net/20.500.13003/18198 https://hdl.handle.net/20.500.12105/23424 35897707 10.3390/ijms23158127 1422-0067 International journal of molecular sciences 2-s2.0-85135383331 839062800001 L2018643355 Inhaled corticosteroids (ICS) use is associated with an increased risk of Pseudomonas aeruginosa (PA) infection in patients with COPD. We aimed to evaluate the effects of ICS on alveolar macrophages in response to PA in COPD patients with and without baseline ICS treatment (COPD and COPD + ICS, respectively) as well as smoker and nonsmoker controls. To do so, cells were infected with PA and cotreated with budesonide (BUD) or fluticasone propionate (FLU). The analysis of NF-?B and c-jun activity revealed a significant increase in both factors in response to PA cotreated with BUD/FLU in smokers but not in COPD or COPD + ICS patients when compared with PA infection alone. The expression of Toll-like receptor 2 (TLR2) and the transcription factor c-jun were induced upon PA infection in nonsmokers only. Moreover, in the smoker and COPD groups, there was a significant increase in TLR2 and a decrease in c-jun expression when treated with BUD/FLU after PA infection, which were not observed in COPD + ICS patients. Therefore, the chronic use of ICS seemingly makes the macrophages tolerant to BUD/FLU stimulation compared with those from patients not treated with ICS, promoting an impaired recognition of PA and activity of alveolar macrophages in terms of altered expression of TLR2 and cytokine production, which could explain the increased risk of PA infection in COPD patients under ICS treatment. eng Effects of Inhaled Corticosteroids on the Innate Immunological Response to Pseudomonas aeruginosa Infection in Patients with COPD research article