2026-08-29T12:38:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/234062024-11-28T21:45:37Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Figueras Castilla, Albert
author
Ballesteros Vizoso, Antonieta
author
Iglesias, Amanda
author
Barceló Bennasar, Antonia
author
Barea-Mendoza, Jesús A
author
Argente del Castillo, Paula
author
Guardiola, Begoña
author
Pérez-Bárcena, Jon
author
Llompart-Pou, Juan Antonio
2024-10-04T13:16:34Z
2024-10-04T13:16:34Z
2022-12-22
Figueras Castilla A, Ballesteros Vizoso MA, Iglesias Coma A, Barceló A, Barea-Mendoza JA, Argente Del Castillo P, et al. Correlation between Thyroid Responses and Inflammatory Cytokines in CriticallyIll COVID-19 Patients. Biomedicines. 2022 Dec;11(1).
10.3390/biomedicines11010026
2227-9059
Biomedicines
https://hdl.handle.net/20.500.13003/18839
36672534
2-s2.0-85146749963
https://hdl.handle.net/20.500.12105/23406
916938000001
Mechanisms involved in thyroid dysfunction in critically ill coronavirus disease 2019 (COVID-19) patients are not clear. Our objective was to correlate the thyroid response with the pro- and anti-inflammatory cytokines profile in critically ill COVID-19 patients. This was a prospective single-center study. We studied the relationship between continuous variables by using Pearson correlation and simple linear regression. Multiple logistic regression analysis was performed to analyze the factors independently associated with mortality. Seventy-eight patients were included in the study at intensive care unit (ICU) admission and 72 had a measurement of the thyroid and inflammatory profile at day 5. No significant correlations were found between thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and inflammatory cytokines at ICU admission. At day 5, fT4, was inversely correlated with IL-10 (p = 0.035). IL-10 was associated with maximum lactate (p < 0.001) and SOFA score values (p = 0.012). The multiple logistic regression analysis showed that there was a significant relationship between IL-10 (day 5) and in-hospital mortality after adjusting by age and severity of illness. In conclusion, we found that the thyroid hormone profile and inflammatory cytokines had a weak correlation at ICU admission. Associations of interest between fT4 and IL-10 were found at day 5. IL-10 at day 5 was found to be correlated with low fT4 and markers of organ failure and death.
eng
Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients
research article