2026-04-29T07:23:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/234012024-11-28T17:44:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16983
Repisalud
author
Razquin, Cristina
author
Ruiz-Canela, Miguel
author
Toledo, Estefanía
author
Clish, Clary B
author
Guasch-Ferré, Marta
author
García-Gavilán, Jesús F
author
Wittenbecher, Clemens
author
Alonso-Gómez, Angel
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Fito, Montserrat
author
Liang, Liming
author
Corella, Dolores
author
Gómez-Gracia, Enrique
author
Estruch, Ramon
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Fiol Sala, Miquel
author
Santos-Lozano, José Manuel
author
Serra-Majem, Lluis
author
Ros, Emilio
author
Aros, Fernando
author
Salas-Salvado, Jordi
author
Hu, Frank B
author
Martínez-González, Miguel A
2024-10-04T13:16:31Z
2024-10-04T13:16:31Z
2022-12-23
Razquin C, Ruiz-Canela M, Toledo E, Clish CB, Guasch-Ferré M, García-Gavilán JF, et al. Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMEDTrial. Int J Mol Sci. 2022 Dec;24(1).
https://hdl.handle.net/20.500.13003/18851
https://hdl.handle.net/20.500.12105/23401
36613713
10.3390/ijms24010270
1422-0067
International journal of molecular sciences
2-s2.0-85146040518
915427700001
L2020986074
Effective prevention and risk prediction are important for peripheral artery disease (PAD) due to its poor prognosis and the huge disease burden it produces. Circulating amino acids (AA) and their metabolites may serve as biomarkers of PAD risk, but they have been scarcely investigated. The objective was to prospectively analyze the associations of baseline levels of plasma AA (and their pathways) with subsequent risk of PAD and the potential effect modification by a nutritional intervention with the Mediterranean diet (MedDiet). A matched case-control study was nested in the PREDIMED trial, in which participants were randomized to three arms: MedDiet with tree nut supplementation group, MedDiet with extra-virgin olive oil (EVOO) supplementation group or control group (low-fat diet). One hundred and sixty-seven PAD cases were matched with 250 controls. Plasma AA was measured with liquid chromatography/mass spectrometry at the Broad Institute. Baseline tryptophan, serine and threonine were inversely associated with PAD (ORfor 1 SD increase = 0.78 (0.61-0.99); 0.67 (0.51-0.86) and 0.75 (0.59-0.95), respectively) in a multivariable-adjusted conditional logistic regression model. The kynurenine/tryptophan ratio was directly associated with PAD (ORfor 1 SD increase = 1.50 (1.14-1.98)). The nutritional intervention with the MedDiet+nuts modified the association between threonine and PAD (p-value interaction = 0.018) compared with the control group. However, subjects allocated to the MedDiet+EVOO group were protected against PAD independently of baseline threonine. Plasma tryptophan, kynurenine/tryptophan ratio, serine and threonine might serve as early biomarkers of future PAD in subjects at a high risk of cardiovascular disease. The MedDiet supplemented with EVOO exerted a protective effect, regardless of baseline levels of threonine.
eng
Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial
research article