2026-04-29T07:24:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/233822024-11-29T07:33:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Pezzani, Raffaele
author
Jiménez-Garcia, Manuel
author
Capó Fiol, Xavier
author
Sönmez Gürer, Eda
author
Sharopov, Farukh
author
Rachel, Tchokouaha Yamthe Lauve
author
Ntieche Woutouoba, David
author
Rescigno, Antonio
author
Peddio, Stefania
author
Zucca, Paolo
author
Tsouh Fokou, Patrick Valere
author
Martorell, Miquel
author
Gulsunoglu-Konuskan, Zehra
author
Ydyrys, Alibek
author
Bekzat, Tynybekov
author
Gulmira, Tussupbekova
author
Hano, Christophe
author
Sharifi-Rad, Javad
author
Calina, Daniela
2024-10-04T13:16:23Z
2024-10-04T13:16:23Z
2022
Pezzani R, Jiménez-Garcia M, Capó X, Sönmez Gürer E, Sharopov F, Rachel TYL, et al. Anticancer properties of bromelain: State-of-the-art and recent trends. Front Oncol. 2022;12:1068778.
2234-943X
https://hdl.handle.net/20.500.13003/18857
https://hdl.handle.net/20.500.12105/23382
36698404
10.3389/fonc.2022.1068778
Frontiers in oncology
2-s2.0-85146901665
922666300001
L2021216931
Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.
eng
Anticancer properties of bromelain: State-of-the-art and recent trends
research article