2026-04-29T07:25:12Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/233822024-11-29T07:33:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Pezzani, Raffaele author Jiménez-Garcia, Manuel author Capó Fiol, Xavier author Sönmez Gürer, Eda author Sharopov, Farukh author Rachel, Tchokouaha Yamthe Lauve author Ntieche Woutouoba, David author Rescigno, Antonio author Peddio, Stefania author Zucca, Paolo author Tsouh Fokou, Patrick Valere author Martorell, Miquel author Gulsunoglu-Konuskan, Zehra author Ydyrys, Alibek author Bekzat, Tynybekov author Gulmira, Tussupbekova author Hano, Christophe author Sharifi-Rad, Javad author Calina, Daniela author 2022 Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases. Pezzani R, Jiménez-Garcia M, Capó X, Sönmez Gürer E, Sharopov F, Rachel TYL, et al. Anticancer properties of bromelain: State-of-the-art and recent trends. Front Oncol. 2022;12:1068778. 2234-943X https://hdl.handle.net/20.500.13003/18857 https://hdl.handle.net/20.500.12105/23382 36698404 10.3389/fonc.2022.1068778 Frontiers in oncology 2-s2.0-85146901665 922666300001 L2021216931 Anticancer properties of bromelain: State-of-the-art and recent trends