2026-04-29T12:24:22Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/233652024-11-28T21:13:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc López-Causapé, Carla author Fraile-Ribot, Pablo author Jimenez-Serrano, Santiago author Cabot, Gabriel author del Barrio-Tofino, Ester author Prado, M. Carmen author Linares, Juana Maria author López-López, Aránzazu author Hurtado, Adoracion author Riera, Elena author Serra, Antoni author Rosello, Eva author Carbo, Lluis author Fernández-Baca, Victoria author Gallegos, Carmen author Saurina, Juan author Arteaga, Emilio author Salom, M. Magdalena author Salva, Antonia author Nicolau Riutort, Antonio author Gonzalez-Candelas, Fernando author Comas, Inaki author Oliver, Antonio author 2022-01-12 Objective: To analyze the SARS-CoV-2 genomic epidemiology in the Balearic Islands, a unique setting in which the course of the pandemic has been influenced by a complex interplay between insularity, severe social restrictions and tourism travels.Methods: Since the onset of the pandemic, more than 2,700 SARS-CoV-2 positive respiratory samples have been randomly selected and sequenced in the Balearic Islands. Genetic diversity of circulating variants was assessed by lineage assignment of consensus whole genome sequences with PANGOLIN and investigation of additional spike mutations.Results: Consensus sequences were assigned to 46 different PANGO lineages and 75% of genomes were classified within a VOC, VUI, or VUM variant according to the WHO definitions. Highest genetic diversity was documented in the island of Majorca (42 different lineages detected). Globally, lineages B.1.1.7 and B.1.617.2/AY.X were identified as the 2 major lineages circulating in the Balearic Islands during the pandemic, distantly followed by lineages B.1.177/B.1.177.X. However, in Ibiza/Formentera lineage distribution was slightly different and lineage B.1.221 was the third most prevalent. Temporal distribution analysis showed that B.1 and B.1.5 lineages dominated the first epidemic wave, lineage B.1.177 dominated the second and third, and lineage B.1.617.2 the fourth. of note, lineage B.1.1.7 became the most prevalent circulating lineage during first half of 2021; however, it was not associated with an increased in COVID-19 cases likely due to severe social restrictions and limited travels. Additional spike mutations were rarely documented with the exception of mutation S:Q613H which has been detected in several genomes (n = 25) since July 2021.Conclusion: Virus evolution, mainly driven by the acquisition and selection of spike substitutions conferring biological advantages, social restrictions, and size population are apparently key factors for explaining the epidemic patterns registered in the Balearic Islands. Lopez-Causape C, Fraile-Ribot PA, Jimenez-Serrano S, Cabot G, del Barrio-Tofino E, Prado MC, et al. A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic Islands. Front Microbiol. 2022 Jan 12;12:803827. 10.3389/fmicb.2021.803827 1664-302X Frontiers in Microbiology https://hdl.handle.net/20.500.13003/19407 35095814 L637029090 2-s2.0-85123417653 https://hdl.handle.net/20.500.12105/23365 747923600001 SARS-CoV-2 Genomic evolution Variants Genomic epidemiology Spike mutations A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic Islands