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00925njm 22002777a 4500 dc Domínguez-López, Inés author Marhuenda-Munoz, Maria author Tresserra-Rimbau, Anna author Hernaez, Alvaro author Moreno, Juan Jose author Martinez-Gonzalez, Miguel Angel author Salas-Salvado, Jordi author Corella, Dolores author Fito, Montserrat author Martinez, Jose Alfredo author Alonso-Gomez, Angel M author Wärnberg, Julia author Vioque, Jesus author Romaguera, Dora author Lopez-Miranda, Jose author Bernal-Lopez, Maria Rosa author Lapetra, Jose author Serra-Majem, Lluis author Bueno-Cavanillas, Aurora author Tur, Josep A author Martín-Sánchez, Vicente author Pinto, Xavier author Delgado-Rodriguez, Miguel author Matia-Martin, Pilar author Vidal, Josep author Vazquez, Clotilde author Daimiel, Lidia author Serra-Mir, Merce author Vazquez-Ruiz, Zenaida author Nishi, Stephanie K author Sorli, Jose V author Castaner, Olga author Abete, Itziar author Vaquero Luna, Jessica author Carabano-Moral, Rosa author Asencio, Alberto author Prohens, Lara author Garcia-Rios, Antonio author Casas, Rosa author Gomez-Perez, Ana Maria author Santos-Lozano, Jose Manuel author Razquin, Cristina author Martinez, Maria Angeles author Saiz, Carmen author Robledo-Pastor, Vanesa author Zulet, Maria Angeles author Salaverria-Lete, Itziar author Eguaras, Sonia author Babio, Nancy author Malcampo, Mireia author Ros, Emilio author Estruch, Ramon author Lopez-Sabater, M Carmen author Lamuela-Raventos, Rosa M author 2021-09 Scope Plasma fatty acids (FAs) are associated with the development of cardiovascular diseases and metabolic syndrome. The aim of our study is to assess the relationship between fruit and vegetable (F&V) consumption and plasma FAs and their subtypes. Methods and Results Plasma FAs are assessed in a cross-sectional analysis of a subsample of 240 subjects from the PREDIMED-Plus study. Participants are categorized into four groups of fruit, vegetable, and fat intake according to the food frequency questionnaire. Plasma FA analysis is performed using gas chromatography. Associations between FAs and F&V consumption are adjusted for age, sex, physical activity, body mass index (BMI), total energy intake, and alcohol consumption. Plasma saturated FAs are lower in groups with high F&V consumption (-1.20 mg cL(-1) [95% CI: [-2.22, -0.18], p-value = 0.021), especially when fat intake is high (-1.74 mg cL(-1) [95% CI: [-3.41, -0.06], p-value = 0.042). Total FAs and n-6 polyunsaturated FAs tend to be lower in high consumers of F&V only in the high-fat intake groups. Conclusions F&V consumption is associated with lower plasma saturated FAs when fat intake is high. These findings suggest that F&V consumption may have different associations with plasma FAs depending on their subtype and on the extent of fat intake. Dominguez-Lopez I, Marhuenda-Munoz M, Tresserra-Rimbau A, Hernaez A, Moreno JJ, Martinez-Gonzalez MA, et al. Fruit and Vegetable Consumption is Inversely Associated with Plasma Saturated Fatty Acids at Baseline in Predimed Plus Trial. Mol Nutr Food Res. 2021 Sep;65(17):2100363. 10.1002/mnfr.202100363 1613-4133 1613-4125 Molecular Nutrition & Food Research https://hdl.handle.net/20.500.13003/19600 34273124 L635636770 2-s2.0-85111347488 https://hdl.handle.net/20.500.12105/23354 678198400001 Dietary fats Mediterranean diet MUFA PREDIMED-Plus PUFA Fruit and Vegetable Consumption is Inversely Associated with Plasma Saturated Fatty Acids at Baseline in Predimed Plus Trial